mitogen-activated protein kinase

(redirected from Mitogen activated protein)

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase

,

MAPK

A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
Using mathematical modeling and experiments in which he tweaked the molecular wiring of the mitogen activated protein kinase (MAPK) pathway that mediates the cells' salt-sensing system, he revealed a sensory misperception: Because of the way the MAPK pathway is set up, the cells interpret an eight-minute oscillation as an ever-increasing staircase of salt concentration.
Using mathematical modeling and experiments in which he tweaked the molecular wiring of the mitogen activated protein kinase (MAPK) pathway that mediates the cells salt-sensing system, he revealed a sensory misperception: Because of the way the MAPK pathway is set up, the cells interpret an eight-minute oscillation as an ever-increasing staircase of salt concentration.
Losmapimod fromGSK 's drug portfolio is an anti-inflammatory drug, which inhibits the p38 mitogen activated protein kinase (MAPK) and is being evaluated in Phase 3 clinical trials.
The aim of the present study was to explore the potential cytotoxic activity of tanapsin on human tumor cells and its underlying mechanisms of cell death, including the activation of the caspase cascade, the mitogen activated protein kinase pathway, the changes in the expression of the Bcl-2 family proteins, as well as the disruption of mitochondrial membrane potential and accumulation of intracellular reactive oxygen species.
DAT has a serine cluster on the distal N-terminus that is phosphorylated in a protein kinase C-dependent manner and a membrane proximal proline-directed site, Thr(T) 53, that is phosphorylated in vitro by Mitogen activated protein kinases.
investigated the role of two kinases, p38 MAPK (a mitogen activated protein kinase) and Chk 1 (a serine/threonine-protein kinase) on cell cycle arrest at the G2 DNA damage checkpoint.
HEXABROMOCYCLODODECANE CAUSES ACTIVATION OF A MITOGEN ACTIVATED PROTEIN IN HUMAN NATURAL KILLER CELL.
Mitogen activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.
NGF/TrkA signaling leads to the PI3K/Akt/ FKHRL1 pathway, that governs the cell survival and the mitogen activated protein kinase (MAPK) pathway that controls cell mitosis (11-13).
9) Mitogen activated protein kinase initiates the oxidative signaling process during T cell cycle entry from G0 to G1 phase transition.
MEK, also known as mitogen activated protein kinase (MAPK) kinase, is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.

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