mitogen-activated protein kinase

(redirected from Mitogen activated protein)

MAP kinase

Any of a family of serine/threonine protein kinases belonging to the CMGC (CDK/MAPK/GSK3/CLK) kinase group, which are involved in cellular responses to various stimuli (e.g., mitogens, osmotic stress, heat shock and cytokines) and regulate cell growth, cycling, differentiation, mitosis and apoptosis.

mitogen-activated protein kinase



A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases.

mitogen-activated protein kinase

Abbreviation: MAPK
A signaling enzyme, i.e., one that circulates extracellularly, influencing cells to begin protein manufacturing. They affect cellular replication and death in inflammatory, ischemic, and malignant diseases.
See also: protein kinase
References in periodicals archive ?
4 TLRs signaling occur via MyD88 dependent or independent pathways that lead to the activation of either p38 or ERK1/2 related mitogen activated protein kinases (MAPK) and subsequent production of either inflammatory cytokines such as TNF-[alpha], IFN-[gamma], and IL-12 or anti-inflammatory cytokines such as IL-4, IL-10.
Recent study reported that eotaxin could activate extracellular signal regulated kinase 2 (ERK2) and p38 mitogen activated protein kinase (MAPK) to stimulate the migration of eosinphils to epithelial cells, then activate, produce and release several inflammatory mediators to induce airway inflammation.
Cheng, "TGF-[beta] regulates the blood-testis barrier dynamics via the p38 mitogen activated protein (MAP) kinase pathway: an in vivo study," Endocrinology, vol.
It is an oral brain penetrant, which is highly selective and a potent inhibitor of the alpha isoform of the protein enzyme p38 mitogen activated protein kinase (p38 MAPK alpha).
The aim of the present study was to explore the potential cytotoxic activity of tanapsin on human tumor cells and its underlying mechanisms of cell death, including the activation of the caspase cascade, the mitogen activated protein kinase pathway, the changes in the expression of the Bcl-2 family proteins, as well as the disruption of mitochondrial membrane potential and accumulation of intracellular reactive oxygen species.
Losmapimod is an inhibitor of p38 mitogen activated protein (MAP) kinase, an enzyme understood to play a central role in the acute inflammation that occurs during a heart attack.
DAT has a serine cluster on the distal N-terminus that is phosphorylated in a protein kinase C-dependent manner and a membrane proximal proline-directed site, Thr(T) 53, that is phosphorylated in vitro by Mitogen activated protein kinases.
investigated the role of two kinases, p38 MAPK (a mitogen activated protein kinase) and Chk 1 (a serine/threonine-protein kinase) on cell cycle arrest at the G2 DNA damage checkpoint.
Protein kinases, in particular the cyclin dependent kinase 2 (cdc2) related kinases (19,22) and mitogen activated protein kinase (MAP kinase) (20) have an important role in phosphorylation of KSP repeats in the carboxyl termini of NF-H and NF-M.
Mitogen activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability.

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