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missense mutation
(redirected from Missense mutations)

   Also found in: Encyclopedia, Wikipedia 0.02 sec.
missense mutation
n.
A mutation in which a base change or substitution results in a codon that causes insertion of a different amino acid into the growing polypeptide chain, giving rise to an altered protein.


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Rachel Karchin, an assistant professor of biomedical engineering, and doctoral student Hannah Carter have revealed that the new process focuses on missense mutations, meaning protein sequences that each possess a single tiny variation from the normal pattern.
Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidism.
Seven of nine MDR W-Beijing strains carried missense mutations in two muT genes (mutT2 and mutT4), and two had a missense mutation in both mutT4 and ogt (Table 1 and 2).
 
 
 
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