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milrinone

   Also found in: Wikipedia 0.01 sec.
milrinone /mil·ri·none/ (mil´rĭ-nōn) a cardiotonic used in the treatment of congestive heart failure.
milrinone [mil´rĭ-nōn]
a cardiotonic used in treatment of congestive heart failure.

milrinone
a synthetic phosphodiesterase inhibitor compound, used to provide inotropic support to the failing myocardium.

milrinone
Primacor® Cardiology A positive inotropic phosphodiesterase inhibitor that provides short-term benefit; it may have a deleterious effects on chronic heart failure. See PROMISE trial.


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In order to improve the hemodynamic profile of the heart and increase cardiac contractility, a physician may also administer an intravenous inotropic agent such as dobutamine (beta-adrenergic agonist) or milrinone (PDE3- inhibitor).
Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heartfailure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study.
ADVERSE REACTIONS Postmarketing Musculoskeletal System Myositis Urogenital System Interstitial Nephritis Primacor (milrinone lactate injection) Primacor Flexible Containers (200 mcg/mL in 5% Dextrose Injection) PRECAUTIONS General There is no experience in controlled trials with infusions of milrinone for periods exceeding 48 hours.
 
 
 
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