microscopic polyangiitis


Also found in: Dictionary, Acronyms, Wikipedia.
Related to microscopic polyangiitis: polyarteritis nodosa

microscopic polyangiitis

systemic, nongranulomatous small-vessel vasculitis, associated with glomerulonephritis, pulmonary capillaritis, palpable purpura, and antineutrophil cytoplasmic autoantibodies.

microscopic polyangiitis

A systemic small-vessel vasculitis that primarily affects the kidneys, skin, and lungs of middle-aged men.

Clinical findings
Fever, malaise, myalgia, weight loss, and autoimmunity, including antineutrophil cytoplasmic antibodies (p-ANCA). Skin lesions occur in 30 to 50%, usually presenting as purpura due to leukocytoclastic vasculitis, less commonly as nodules involving the vessels of the dermis and subcutaneous fat and ulcers. The kidney shows rapidly progressive focal and segmental glomerulonephritis.

DiffDx
Polyarteritis nodosa.

microscopic polyangiitis

Hypersensitivity angiitis, microscopic periarteritis, microscopic polyarteritis Internal medicine The term recommended for necrotizing vasculitis with few or no immune deposits, affecting small vessels–ie, arterioles, capillaries, venules; MP is often accompanied by ANCA, necrotizing glomerulonephritis and pulmonary capillaritis. See Small vessel vasculitis, Systemic vasculitis.

mi·cro·scop·ic pol·y·an·gi·i·tis

(mī'krŏ-skop'ik pol'ē-an'jē-ī'tis)
Systemic, nongranulomatous small-vessel vasculitis, associated with glomerulonephritis, pulmonary capillaritis, palpable purpura, and antineutrophil cytoplasmic autoantibodies.
References in periodicals archive ?
Recombinant activated factor VII for diffuse alveolar hemorrhage in microscopic polyangiitis.
In a study conducted in the United Kingdom from 1988 to 1994, the incidence of microscopic polyangiitis was 3.
cANCA is positive in 75-90% of Wegener granulomatosis cases, and pANCA positivity is most commonly seen in microscopic polyangiitis (Mansi et at.
Symptoms of Microscopic polyangiitis (MPA) include fatigue, fever, decreased appetite, rapid and sudden weight loss, rashes, muscle aches, joint pain, cough, shortness of breath, coughing up blood and abdominal pain with food.
Treatment of polyarteritis nodosa and microscopic polyangiitis with poor prognosis factors: a prospective trial comparing glucocorticoids and six or twelve cyclophosphamide pulses in sixty-five patients.
Vasculitis involving the small vasculature includes Henoch-Schonlein purpura, essential cryoglobulinemia, hypersensitivity vasculitis, vasculitis secondary to an autoimmune connective tissue disease, vasculitis secondary to viral infection, and vasculitis associated with antineutrophil cytoplasmic antibodies (ANCA), including Wegener's granulomatosis, (3, 4) Churg-Strauss granulomatosis, (2, 5, 6) microscopic polyangiitis (MPA), (7, 8) and the renal limited form of MPA sometimes known as pauci-immune glomerulonephritis or idiopathic crescentic glomerulonephritis.
Rituxan also gained approval as a combination treatment (with corticosteroids) for adults with Wegener's granulomatosis and microscopic polyangiitis.
Although liver dysfunction from microscopic polyangiitis is very rare, especially at presentation, this diagnostic possibility should be kept in mind to permit prompt consideration of steroid therapy.
Food and Drug Administration today approved Rituxan (rituximab), in combination with glucocorticoids (steroids), to treat patients with Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA), two rare disorders that cause blood vessel inflammation (vasculitis).
A 29-year-old woman who presented in the 16th week of her third intrauterine pregnancy was diagnosed as having active microscopic polyangiitis.

Full browser ?