Michaelis-Menten kinetics


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Michaelis-Menten kinetics

Etymology: Leonor Michaelis, American biochemist, 1875-1949; Maud L. Menten, Canadian physician in U.S. practice, 1879-1960
a method of transforming drug plasma levels into a linear relationship by using the parameters of drug concentration and a constant, Km, which is a measure of enzyme-substrate affinity. This is necessary when drug elimination mechanisms are saturable rather than proceeding by first-order kinetics.
References in periodicals archive ?
The basic of kinetics of ammonium and nitrite oxidation was calculated with Michaelis-Menten kinetics equation using the Lineweaver-Burk plots [37].
First, Michaelis-Menten kinetics are an approximation (Bardsley et al.
The rate equation describing the degradation process of an individual substrate by the activated sludge can be based on the kinetics for oxygen and substrate acting as rate-limiting factors at a constant biomass concentration analogous to the Michaelis-Menten kinetics.
In contrast to Michaelis-Menten kinetics, which is used to describe a process catalyzed by a single enzyme, Monod kinetics describes processes (both growth and growthlinked biodegradation) of a more complex nature in which many enzyme systems are involved.
elimination kinetics) of orally administered alcohol is confounded by the variability in alcohol absorption, especially because alcohol elimination rates nearly are independent of systemic alcohol concentration and follow Michaelis-Menten kinetics.
raphanistrum roots exhibited typical Michaelis-Menten kinetics similar to results reported for purified sweet potato APase (Rao and others 1998).
Using Michaelis-Menten kinetics to analyze their data, they determined that the [K.
At 10 mL/L DMSO, Michaelis-Menten kinetics were observed, which were not attainable at lower DMSO concentrations (12).
Michaelis-Menten kinetics were fitted using nonlinear regression analysis (Sigmaplot for Windows 4.
This method has been reported to give plots to which Michaelis-Menten kinetics apply X10].
However, TCE blood levels in the liver are nonlinearly correlated to saturable Michaelis-Menten kinetics of the quantitatively predominant oxidative TCE metabolism.