Michaelis-Menten kinetics


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Michaelis-Menten kinetics

Etymology: Leonor Michaelis, American biochemist, 1875-1949; Maud L. Menten, Canadian physician in U.S. practice, 1879-1960
a method of transforming drug plasma levels into a linear relationship by using the parameters of drug concentration and a constant, Km, which is a measure of enzyme-substrate affinity. This is necessary when drug elimination mechanisms are saturable rather than proceeding by first-order kinetics.
References in periodicals archive ?
Inhibition of ureases by compounds 1c-10c is not time dependent and is perfectly fixed to Michaelis-Menten kinetics.
The basic of kinetics of ammonium and nitrite oxidation was calculated with Michaelis-Menten kinetics equation using the Lineweaver-Burk plots [37].
Bardsley, WG, Leff, P, Kavanagh, J and Waight, RD, "Deviations from Michaelis-Menten kinetics.
Discrimination among eight modified Michaelis-Menten kinetics models of cellulose hydrolysis with a large range of substrate/enzyme ratios.
First, Michaelis-Menten kinetics are an approximation (Bardsley et al.
The rate equation describing the degradation process of an individual substrate by the activated sludge can be based on the kinetics for oxygen and substrate acting as rate-limiting factors at a constant biomass concentration analogous to the Michaelis-Menten kinetics.
This fact shows that the reactions exhibit 1 to zero order kinetics with respect to all diols indicating Michaelis-Menten kinetics.
In contrast to Michaelis-Menten kinetics, which is used to describe a process catalyzed by a single enzyme, Monod kinetics describes processes (both growth and growthlinked biodegradation) of a more complex nature in which many enzyme systems are involved.
Wagner ([10]) developed another open 1-compartment model, with the difference that the clearance of alcohol is now described by Michaelis-Menten kinetics (see Figure 2.
elimination kinetics) of orally administered alcohol is confounded by the variability in alcohol absorption, especially because alcohol elimination rates nearly are independent of systemic alcohol concentration and follow Michaelis-Menten kinetics.
Notice that there are two distinct parts to the curve generated by Michaelis-Menten kinetics.