Michaelis-Menten kinetics

(redirected from Michaelis-Menten constant)
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Michaelis-Menten kinetics

Etymology: Leonor Michaelis, American biochemist, 1875-1949; Maud L. Menten, Canadian physician in U.S. practice, 1879-1960
a method of transforming drug plasma levels into a linear relationship by using the parameters of drug concentration and a constant, Km, which is a measure of enzyme-substrate affinity. This is necessary when drug elimination mechanisms are saturable rather than proceeding by first-order kinetics.
References in periodicals archive ?
Fluorometry was used to quantify reaction products, and the Michaelis-Menten constant, K[sub.
The Michaelis-Menten Constant (Km) values ranged between 510 and 570 mM.
Using Lineweaver-Burk plots, we estimated graphically the apparent Michaelis-Menten constants, maximum velocity ([V.