metabotropic glutamate receptor

(redirected from Mglur)

metabotropic glutamate receptor

A G protein-coupled receptor that mediates its effects by enzyme activation.
mGluRs can be subdivided into three groups (I–III) according to their sequence similarity, transduction mechanism and pharmacological profile.
References in periodicals archive ?
Activation of Group II mGluRs (mGluR2/3) could also be used to treat parkinsonian motor symptoms because of decreased excitatory glutamate transmission at corticostriatal synapses.
NFC-1 is entering Phase 2/3 for the treatment of mGluR network mutation positive Attention Deficit Hyperactivity Disorder (mGluR+ ADHD), as well as neuropsychiatric symptoms resulting from a related rare genetic disorder, 22q11.
Inhibition of mGluR is a promising therapeutic strategy for autism disorders, including Fragile X, but the brain region responsible for this effect is not known.
Grueter and colleagues (2006) identified a mGluR5-mediated form of LTD induced by activation of group 1 mGluR receptors.
El uso de antagonistas mGluR, como el 2-metil-6-(feniletinil)-piridina (MPEP) y el CTEC, ha dado como resultado un rescate de la morfologia de las espinas dendriticas, sintesis proteica, la atrofia en el hipocampo, y parcialmente el macroorquidismo en modelos animales (3,50).
With Preso1 so pivotal for regulating group 1 mGluR activity, it could prove a useful new target for drugs to treat a variety of health problems in which these receptors are thought to play a role, including chronic pain, schizophrenia, Alzheimer's disease, and fragile X syndrome, Worley added.
From his studies in both areas, Stern knew two things: PI3K/Tor was the major pathway for insulin signals within cells, and insulin could affect synapses in a remarkably similar way to the mGluR defects associated with autism.
Queen and colleagues (1993) found a reduction in mGluR function in the hippocampus of adult offspring from rats exposed to ethanol during pregnancy (at a blood ethanol level of 0.
Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats.
These receptors are a member of the group III mGluR and are widely distributed throughout the central nervous system.
A recent pivotal study showed that mGluR5--the major group 1 mGluR in the forebrain--contributes significantly to the pathogenesis of fragile X (Neuron 2007;56:955-62).
2004) The mGluR theory of fragile X mental retardation, Trends in Neurosciences, 27(7), pp.