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mevalonic acid
(redirected from Mevalonate)

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
mevalonic acid
a step in the synthesis of cholesterol in the body. It is the rate of synthesis limiting step and the site of dietary control.

mevalonic acid
A molecular precursor of many endogenous molecules–eg, cholesterol, coenzyme Q, carotenoids, dolichol, steroids, and terpenes


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Mevalonate Pathway and Dolichol inhibition All statins, regardless of brand, are reductase inhibitors.
Inhibition of HMG-CoA reductase by statin results in decreased synthesis of cholesterol and other products downstream of mevalonate, which may produce adverse effects in statin therapy.
Classical work by Bloch, Cornforth and Lynen on mammalian and yeast cells in the 1950s culminated in the elucidation of the mevalonate pathway for the biosynthesis of the universal isoprenoid precursors, isopentenyl diphosphate (IPP) (7) and dimethylallyl diphosphate (DMAPP) (8) via acetyl-CoA (11), 3-hydroxy-3-methylglutaryl-CoA (10) and 5-diphospho-mevalonate (9) (for review, see Qureshi and Porter, 1981; Bach, 1995; Bloch, 1992; Bochar et al.
 
 
 
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