During 1984 to 1992, we observed substantial year-to-year variations in cure rates (conversion from egg-positive to egg-negative status on urine Nuclepore filtration examination) for both praziquantel and metrifonate (Table 1).
Prevalence of infection at 12 months after treatment (interval change in geometric mean of (egg count + 1) for group) Year treated with PZQ or metrifonate Patient's infection and treatment status 1984 1985 Egg-positive urine, 17% 12% Given PZQ, never (97 to 1.
A number of other cholinergic drugs--including physostigmine SR, metrifonate
, velnacrine, rivastigmine, glantamine, and eptastigmine--are poised for approval by the FDA.
In fact a related compound, metrifonate
, is a potential treatment but tests on it were halted after patients suffered "muscle weakness and breathing difficulties".
The drug, Metrifonate
, doesn't stop the brain cells from continuing to die, but it does make the ones that are remaining work twice as hard.
GOOD news for carers of people with Alzheimer's disease - metrifonate, which started life years ago as a treatment for tropical liver fluke disease, has shown excellent results in early Alzheimer's.
I'm told that the licence for metrifonate in Britain was applied for last year, so that, given no last-minute problems, it should be available early next year.
However tacrine should be used as a benchmark for the evaluation of other aminoacridines such as donepezil, galantamine and metrifonate
as anti-dementia drugs.
, which has been used to treat tropical infections, is set to revolutionise dementia therapy, while Exelon is designed specifically for Alzheimer's.
and anticholinesterases, such as donepezil, metrifonate
, rivastigmine, etc.
Other cholinesterase inhibitors in the developmental pipeline include metrifonate
, an irreversible inhibitor of cholinesterase, and rivastigmine, whose marketing application is under review at the Food and Drug Administration, he said.
, another cholinesterase inhibitor that has shown promise in clinical trials, can reduce hallucinations, apathy, and aberrant movements associated with Alzheimer's.