methylation

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methylation

 [meth″ĭ-la´shun]
the addition of methyl groups.

meth·yl·a·tion

(meth-i-lā'shŭn),
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid, the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

[-lā′shən]
Etymology: Gk, methy, wine, hyle, matter
1 the introduction of a methyl group, CH3, to a chemical compound.
2 the addition of methyl alcohol and naphtha to ethanol to produce denatured alcohol.

methylation

Chemistry
The addition of a methyl group to a molecule.
 
Molecular biology
The addition of a methyl group to a cytosine residue on double-stranded DNA, a process which plays a major role in regulating gene expression and preventing restriction endonucleases from cutting DNA at their recognition sites.
 
Methylated genes are inactive; the pattern of methylation or imprinting is critical in gene expression, and may be passed from one generation to the next. Genes may be demethylated or methylated de novo according to the cell’s function, or during normal development. Phosphorylation is another form of semi-permanent gene control.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid; the net effect being to reduce tissue basophilia and abolish metachromasia.

methylation

the addition of a methyl group (-CH3) to an AMINO ACID in a PROTEIN, as in, for example, POST-TRANSLATIONAL MODIFICATION, or to a NUCLEOTIDE in a NUCLEIC ACID; see MODIFICATION AND RESTRICTION SYSTEM. See also METHYL TRANSFERASE.

methylation,

n a phase-II detoxification pathway in the liver; methyl groups combine with toxins to rid the body of various substances.

meth·yl·a·tion

(meth'i-lā'shŭn)
Addition of methyl groups; in histochemistry, used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid.

methylation

(meth´əlā´shən),
n 1. the introduction of a methyl group, CH3, to a chemical compound.
n 2. the addition of methyl alcohol and naphtha to ethanol to produce denatured alcohol.

methylation

the addition of methyl groups.
References in periodicals archive ?
In addition, we evaluated associations of 20 SNPs reported to be associated with arsenic methylation capacity in prior candidate gene studies.
These results suggest that among common variants captured on our genotyping platform, AS3MT SNPs are the major genetic determinants of arsenic methylation capacity in this population and that contributions of other common variants to methylation capacity are substantially weaker than the effects of AS3MT variants.
32/AS3MT region with arsenic methylation capacity is consistent across many candidate gene studies (Agusa et al.
The effects associated with higher levels of well-water arsenic and lower methylation capacity on heart disease risk were at least additive.
Previous studies have reported evidence of adverse effects of incomplete arsenic methylation capacity on cancer risk.
Our hypothesis was that selenium would increase the methylation capacity, as shown in previous reports (Christian et al.
shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells.
The relationship between methylation capacity and skin lesions needs further investigation.
Abnormal methylation capacity in human liver cirrhosis.
III] methylation, but also other organs, especially the kidneys, have been shown to exert methylation capacity (Abernathy et al.
1998), differences in the methylation capacity could be of importance.