strontium-89 chloride

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strontium-89 chloride

(stron-tee-um) ,

Metastron

(trade name)

Classification

Therapeutic: nonopioid analgesics
Pharmacologic: radiopharmaceuticals
Pregnancy Category: D

Indications

Treatment of bone pain in patients with painful skeletal metastases.

Action

Preferentially taken up by bone tumors and metastatic bone lesions, where selective irradiation takes place.

Therapeutic effects

Decreased pain from bony metastases. Because of delayed onset, adequate analgesia should be provided until effects of strontium are evident.

Pharmacokinetics

Absorption: IV administration results in complete bioavailability.
Distribution: Selectively localized in and retained by metastatic bone lesions. Excreted in breast milk.
Metabolism and Excretion: 67% excreted in urine, 33% in feces.
Half-life: (physical half-life) 50.5 days.

Time/action profile (pain relief)

ROUTEONSETPEAKDURATION
IV7–20 daysvariable6 mo (range 4–12 mo)

Contraindications/Precautions

Contraindicated in: Lactation: Lactation; Obstetric: Pregnancy.
Use Cautiously in: Women with childbearing potential; Pediatric: Children <18 yr (safety not established); Patients with platelet counts <60,000 mm3 or WBCs <2400 mm3; Diminished bone marrow reserve or other chronic debilitating illness; Patients with a life expectancy <1–3 wk.

Adverse Reactions/Side Effects

Hematologic

  • anemia
  • neutropenia
  • thrombocytopenia

Musculoskeletal

  • transient increase in bone pain

Interactions

Drug-Drug interaction

Additive bone marrow toxicity with antineoplastics or previous radiation therapy.Calcium-containing medications may ↓ bone uptake and effectiveness of strontium (discontinue 2 wk prior to strontium; may resume 2 wk after strontium).

Route/Dosage

Intravenous (Adults) 148 megabecquerels (4 millicuries) or 1.5–2.2 megabecquerels/kg (40–60 microcuries/kg), not to be repeated sooner than 90 days.

Availability

Radioactive injection: 10.9–22.6 mg/mL (148 megabecquerels or 4 millicuries) in 10-mL vials, 13.4–20.1 mg/mL (150 megabecquerels or 4.05 millicuries) in 10-mL vials

Nursing implications

Nursing assessment

  • Assess pain (intensity, location) periodically throughout therapy. Patient may experience a transient increase in bone pain for 2–3 days, beginning 2–3 days after administration. This is normal, and increasing analgesic doses may be required. Pain should begin to diminish after 1–2 wk or longer and may allow for reduction or discontinuation of analgesics. Effects may continue for several months.
  • Lab Test Considerations: Monitor hematologic parameters (WBC, platelets) at least once every other week during therapy. Platelets are usually ↓ 30% from preadministration levels. The nadir of thrombocytopenia is 12–16 wk. Leukopenia may also occur. Recovery to preadministration levels usually occurs within 6 mo.

Potential Nursing Diagnoses

Acute pain (Indications)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)

Implementation

  • Should be administered only in facilities with personnel experienced in the safe use and handling of radiopharmaceuticals.
    • Incontinent patients should have urinary catheters placed prior to administration to minimize the risk of radioactive contamination of clothing, linens, and the environment.
  • Intravenous Administration
  • Administered by slow injection over 1–2 min. A flushing sensation may be experienced following a rapid (<30 sec) injection.

Patient/Family Teaching

  • Instruct patient to continue taking pain medication until strontium-89 becomes effective. Analgesic doses may be decreased once the effects of strontium are known.
  • Advise patient that no change in eating or drinking is necessary. Alcohol and caffeine need not be avoided unless advised by health care professional.
  • Strontium-89 is present in the blood and urine for 1 wk following injection. During the 1st wk, the patient should be instructed to use a normal toilet rather than a urinal if possible and to flush twice after use. Spilled urine or blood from a cut should be wiped up with a tissue and flushed. Good handwashing should be observed, and any linen contaminated with blood or urine should be immediately washed separately from other items and rinsed thoroughly. If any urine collection device is used, the instructions on its use should be followed.
  • Instruct patient not to receive any vaccinations during therapy without consulting health care professional.
  • Instruct patient to notify any health care professional or caregiver of strontium-89 therapy prior to treatment.
  • Advise patient to contact health care professional if the effects of strontium-89 decrease and pain returns.
  • May cause infertility. Counsel patient prior to therapy. Advise female patients to notify health care professional immediately if pregnancy is planned or suspected, or if breastfeeding.
  • Emphasize the importance of periodic blood tests.

Evaluation/Desired Outcomes

  • Decrease in pain due to bony metastases. Repeat administration is based on patient’s response to therapy, current symptoms, and hematologic status. Repeat doses are not recommended at intervals of <90 days.
References in periodicals archive ?
Contractor name : ET METASTRON M 91 - MICHAEL SPASSOV, UIC 102079595
Table 17: US Market for Radiopharmaceutical Bone Palliation Procedures (2005): Percentage Share Breakdown by Key Radiotherapeutics - Metastron, Quadramet and Sr-89 (includes corresponding Graph/Chart) II-36 Radiopharmaceuticals Market - A Peek Into the Recent Past II-37
In addition, we continued to strive to diminish the impact of adverse market and industry trends with the addition of new collaborations and opportunities as demonstrated through our Bexxar and Metastron agreements with Amersham Health, our enhanced adjuvant license agreement with Wyeth Lederle Vaccines and our recently announced license and collaboration agreement with Beaufour Ipsen.
METASTRON is an injectable radiopharmaceutical indicated for the relief of bone pain in patients with painful metastases.
More information about METASTRON is available at www.
The Company also markets Metastron (R) (strontium-89 chloride) for the palliation of bone pain associated with the spread of cancer.
Its leadership in radiopharmaceuticals and brachytherapy is exemplified further by innovative products such as Ceretec (Technetium Tc-99m Exametazime Injection) used in brain imaging and in white blood cell labeling to detect infection and inflammation; Metastron
Physicians will have access to technical information on METASTRON including clinical trials that demonstrate pain control for up to 6 months.
It is the leader in innovative products and services for nuclear medicine, and is the sole supplier of Ceretec (technetium 99m-exametazine injection), used for brain imaging and labeling white blood cells to detect infection and inflammatory processes; Metastron (strontium-89 chloride injection), a palliation therapy for bone cancer that has metastasized from other sites (usually prostate or breast cancer); I-125 Seeds and I-125 RAPID Strand (implantable devices for early-stage prostate cancer); and a number of other proprietary radiopharmaceuticals.
In early 1993, Zeneca entered into an arrangement with Amersham International whereby we would co-promote the radiopharmaceutical treatment, Metastron, in most territories of the world.
Metastron is a radiopharmaceutical treatment for relief of pain from cancer that spreads to bone.