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3 Bone Metastases Therapeutics: Market Characterization 17
For each patient, we collected information on baseline characteristics, such as age, sex, date of nephrectomy, prognostic class based on the Heng criteria, (14) and site of metastases at the beginning of the third-line treatment.
In Table III, details of the sites of bone and other metastases, modalities used to demonstrate bony metastases, complications of disease, and patients, progress are shown.
The 2 cases presented here demonstrate extensive spinal canal drop metastases, occupying almost the entire canal from the craniocervical junction down to the lumbosacral spine.
In patients with initially unresectable metastases, one of the challenges is to downsize the metastases so that they become resectable.
Reports from two phase II studies of denosumab for treating patients with bone metastases from solid tumors showed that the drug was at least as effective as an intravenous bisphosphonate for reducing a plasma marker of bone resorption.
It can detect occult metastases in about 10-20% of cases of non-small cell lung carcinoma (NSCLC)[9-11].
6% of the patients in the treatment group developed symptomatic brain metastases compared with 40.
Cutaneous metastases from carcinoma are relatively uncommon in clinical practice, but it is very important that they are recognized since the appearance of cutaneous metastases signals widespread metastatic disease, resulting in a poor prognosis.
Scientists today don't hold that cancer cells are dispersed randomly throughout the body, so that only growth conditions in different organs determine the distribution of metastases.
The diagnostic accuracy of TPS and TPA was investigated for any CNS metastases, parenchymal brain metastases, and for leptomeningeal carcinomatosis.
There is a need for effective drugs for patients with cancer metastases in the brain," said Stephen M.