67) The function of GON-1, a homolog of human ADAMTS9 metalloprotease
, made us recognize that an important domain (GON domain) in the C-terminus, which is not related to protease but plays a critical role for cells to normally secrete proteins, has been ignored because the metalloprotease
domain is so obvious.
A ~90 kDa band was observed by zymography corresponding to metalloprotease
Patients who reached success at 12 weeks were those who started with lower baseline levels of matrix metalloprotease
, or lower or intermediate baseline levels of serine protease," Dr.
Large multimers are assembled in a normal fashion but straight after secretion they bind spontaneously to platelets and are cleaved by ADAMTS 13, a disintegrin-like and metalloprotease
domain with thrombosponding type 1 motifs (12).
The Extracellular metalloprotease
of Vibrio tubiashii is a major virulence factor for Pacific oyster (Crassostrea gigas) larvae.
Polymorphisms in a disintegrin and metalloprotease
33 gene and the risk of chronic obstructive pulmonary disease: a meta-analysis.
As stated, a number of disease states involve overexpression of matrix metalloproteases
, and there exist diseases in which mutations result in overexpression of MMP-13 and premature development of osteoarthritis.
CD 10 is a single-chain, 90-110-kDa cell surface zinc dependent metalloprotease
inactivating various bioactive neuropeptides.
9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.
A disintegrin-like and metalloprotease
(reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.
Membrane type 1 matrix metalloprotease
cleaves laminin-10 and promotes prostate cancer cell migration.
(MMP) is an endopeptidase expressed in human urine whenever cancer is present.