metabotropic receptor

(redirected from Metabotropic receptors)
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me·tab·o·tro·pic re·cep·tor

a type of receptor that is linked to intracellular production of 1,2-diacylglycerol and inositol 1,4,5-trisphosphate.
[metabolism + G. tropē, turning, inclination, + -ic]

metabotropic receptor

A type of G protein-coupled membrane receptor indirectly linked to ion-channels through signal transduction, typically by G protein signalling. In contrast to ionotropic receptors—which form ion channels and when activated open those channels to ions such as Na+, K+ or Cl-, allowing their flow in or out of cells—metabotropic receptors do not form ion channels. Metabotropic receptor activation triggers intracellular events that lead to the production of second messengers, which influence ionotropic receptors and ion channel opening.
References in periodicals archive ?
Binding of glutamate to metabotropic receptors involves guanosine nucleotide-binding protein (G-protein).
The modulation of glutamatergic ionotropic or metabotropic receptors is shown in Table 4.
Metabotropic receptors generally produce slower and longer-lasting reactions at the synapse that have modulatory effects rather than generate new nerve signals.
So-called metabotropic receptors , responding to the same neurotransmitters, set off chemical cascades in the receiving nerve cells, so-called "second messenger" systems, chains of chemical processes activating synthesis of neurotransmitters, of receptors and of modulators, changing the reactivity of the nerve cell and of the system it subserves.
AMPA, NMDA, and metabotropic receptors have been found in the vestibular nuclei.
Thirteen chapters deal with N-methyl-n-aspartate (NMDA) receptors, 8 with 2-amino-3-hydroxy-5-methyl-4-isoxazole propicnic acid (AMPA) receptors, 6 with kainate receptors, and 6 with metabotropic receptors.