As a new omics technique, metabonomics
was defined as quantitative measurement of time-related multiparametric metabolic response of multicellular systems to pathophysiological stimuli or generic modification (Nicholson et al.
281, 282 (2001) ("The development of genomics, proteomics (the measurement of specific proteins) and metabonomics
(the study of metabolite profiles of either intrinsic or xenobiotic molecules), combined with a greater knowledge of individual genetic polymorphisms, will offer new paradigms for hazard evaluation and risk assessment.
Products that Waters sells for metabolomics applications include the Q-Tof Premier Q-TOF MS system, the Waters Metabonomics
UPLC/MS/MS system, and Metabolynx, a software package that interprets MS data.
Other technologies of relevance to the field of biomarkers that are not covered by the immuno and molecular sectors umbrella include metabonomics
 and mass spectrometry .
Effect of dexamethasone on the metabonomics
profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.
The researchers looked at the new science of metabonomics
to examine how human metabolism might interact with certain drugs, the environment and bacteria in the gut.
This study indicated that the UPLC-Q/TOF MS-based metabonomics
not only gave a systematic view of the pathomechanism of AS, but also provided a powerful tool to study the efficacy and mechanism of complex TCM prescriptions.
Liquid chromatography-tandem mass spectrometry-based plasma metabonomics
delineate the effect of metabolites' stability on reliability of potential biomarkers.
The aim of metabonomics
is to measure the "global, dynamic metabolic response of living systems to biological stimuli" (Nicholson and Lindon 2008).
Erika Erickson, the 2010 winner of the Nobel Prize in Physiology or Medicine for her contributions to human metabonomics
, which studies the comprehensive, dynamic metabolic response to biological stimuli or genetic manipulation.
Other cutting edge technologies might be possibilities for alternative methods, including genomics, proteomics and metabonomics
, but these techniques are not yet ready for service in this capacity.
serves the field of toxicology by providing a quantitative measurement of time-related multi-parametric metabolic responses of living systems to patho-physiological stimuli or genetic modification.