In the CB control rats, the urinary space and the mesangial cells
within the glomerulus was swollen due to oedema; while enlarged proximal convoluted tubule and distal convoluted tubules was observed.
Salvianolate inhibits proliferation and endothelin release in cultured rat mesangial cells
Indeed, no other renal lipidosis shows prominent and widespread myelin bodies in podocytes, mesangial cells
, endothelial cells, proximal tubules, interstitial cells, and arterial endothelial cells.
Previous study has reported that the BMP7- induced inhibition of TGF-ss-dependent profibrogenic activities in mesangial cells
requires SMAD5 (Wang and Hirschberg, 2004).
sup] Estrogen treatment increased the expression and activity of MMP-9 in in mesangial cells
isolated from glomerulosclerosis-resistant mice, predominantly through estrogen receptor (ER) a activation.
29 In another study it was observed that EGb761 delays the development of glomerulosclerosis by preventing hypertrophy and accumulation of extracellular matrix in the mesangial cells
of diabetic rats.
Metformin inhibits nuclear factorkappaB activation and inflammatory cytokines expression induced by high glucose via adenosine monophosphate-activated protein kinase activation in rat glomerular mesangial cells
37 High levels of reactive oxygen species in endothelial and mesangial cells
were also demonstrated.
TNF-[alpha] is cytotoxic to glomerular and mesangial cells
and could directly cause renal injury (Kolati et al.
Inhibitors of proliferation of mesangial cells
, for example, leukotriene antagonists, may offer therapeutic options for the treatment of proliferative glomerular diseases .
Sasayama, "Inhibitory effects of rosmarinic acid on the proliferation of cultured murine mesangial cells
," Nephrology Dialysis Transplantation, vol.
b) Mild increase in mesangial cells
and moderate expansion of the mesangial matrix.