Merkel cell

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Merkel cell, Merkel disk

found in the basal layer of the epidermis; believed to act as slow-acting tactile endorgans.

Merkel cell tumor
see neuroendocrine cell tumor.
References in periodicals archive ?
Since Merkel cells are found within the basal layer of the epidermis (13), it is unlikely that they are collected in surface-swabs.
6) This malignancy originates from Merkel cells, which are believed to be primary neural cells expressing neurosecretory (dense core) granules.
Merkel cells were first described in 1875 by Friedrich Sigmund Merkel as large, clear, oval cells found in the basal epidermal layer of skin, hair follicles, and oral mucosa.
Merkel cells are neuroendocrine cells that reside in the vertebrate epidermis, passing mechanical stimuli on to sensory neurons.
Whether and how the virus is translated from the respiratory tract to skin cells, if it is able to be transported systemically, and its role in the malignant transformation of Merkel cells are all questions worthy of further investigation.
Specifically, the tumors contained cells that resembled Merkel cells, a type of neuroendocrine cells that were first described in 1875 by German anatomist and pathologist Friedrich Sigmund Merkel.
Washington, June 19 (ANI): An American study has confirmed that light touch-the sense that lets musicians find the right notes on a keyboard, a seamstress revel in the feel of cool silk, the artisan feel a curve in material and the blind read Braille-depends upon the activity of Merkel cells, which are found in the crescent-shaped clusters in the skin.
In addition to carcinoids of the lung, rectum, common bile duct, and appendix, immunohistochemical staining for pancreatic polypeptide has been described in some cortical neurons of the brain,[9] in epidermal Merkel cells of psoriatic skin lesions,[10] and in specialized epithelium such as Barrett esophagus.
20] Initially described in 1972, Merkel cell carcinomas are aggressive primary tumors of the skin and are thought to be the malignant counterpart of resident neuroendocrine Merkel cells.
1,12] In contrast, CK20 is found in more complex epithelia from the gastrointestinal tract (such as the gastric and intestinal mucosa), genitourinary tract (urothelium), squamous epithelia from any site, and Merkel cells.
Merkel cells and Merkel cell tumors: ultrastructure, immunocytochemistry and review of the literature.
The team showed that skin cells called Merkel cells can sense touch and that they work virtually hand in glove with the skin's neurons to create what we perceive as fine details and textures.