Merkel cell carcinoma


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Merkel cell carcinoma

[mer′kəl, mur′kəl]
Etymology: Friedrich S. Merkel, German anatomist and physiologist, 1845-1919
a rapidly growing malignant skin tumor that tends to occur on sun-exposed surfaces of older Caucasian individuals. It is composed of small cells in a trabecular pattern that contain dense core granules.
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Merkel cell carcinoma

Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Associations
Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
 
DiffDx
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
 
Prognosis
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Management
Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
Clinicopathological and immunohistochemical analysis of 20 cases of Merkel cell carcinoma in search of prognostic markers.
Merkel cell carcinoma of the head and neck: A single institutional experience.
Samimi stressed that the newly shown association that she and her coworkers have found between vitamin D deficiency and worse-prognosis Merkel cell carcinoma must be considered hypothesis-generating rather than proof of causality Serum vitamin D wasn't measured until an average of 3 months after cancer diagnosis.
Sivelli R, Ghirarduzzi A, Del Rio P et al: Giant Merkel cell carcinoma of the left arm.
Deletion mapping on the short arm of chromosome 1 in Merkel cell carcinoma.
Complete spontaneous regression in Merkel cell carcinoma.
Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck.
He and his associates devised the acronym AEIOU to describe the clinical features of Merkel cell carcinoma based on an analysis of 195 patients given the diagnosis between 1980 and 2007 (J.
Brudnoy, who based his radio show at legendary news-talk station WBZAM, died in Boston on December 9 of the rare skin cancer Merkel cell carcinoma.
In addition, there are reports of increased risk of several rare malignancies and proliferative lesions, including Merkel cell carcinoma, squamous cell carcinoma of the conjunctiva, and multicentric Castleman's disease.
Simon, president of Goodstein Commercial Realty and a prominent member of New York's real estate community, died last week at the age of 69 from merkel cell carcinoma.