Merkel cell carcinoma


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Merkel cell carcinoma

[mer′kəl, mur′kəl]
Etymology: Friedrich S. Merkel, German anatomist and physiologist, 1845-1919
a rapidly growing malignant skin tumor that tends to occur on sun-exposed surfaces of older Caucasian individuals. It is composed of small cells in a trabecular pattern that contain dense core granules.
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Merkel cell carcinoma

Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Associations
Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
 
DiffDx
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
 
Prognosis
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Management
Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
Asked by the audience if she screens her patients with Merkel cell carcinoma or melanoma for vitamin D deficiency, Dr.
Poulsen M, Round C, Keller J, et al: Factors influencing relapse-free survival in Merkel cell carcinoma of the lower limb-a review of 60 cases.
We are very pleased with the progress of the JAVELIN clinical development program and we are looking forward to presenting additional data on the potential of this investigational compound in Merkel cell carcinoma and other tumor types in 2016.
Teresa Fernandez-Figueras noted that a recent analysis of more than 3 decades of Surveillance, Epidemiology, and End Results (SEER) registry data indicated there are about 1,500 new cases of Merkel cell carcinoma per year in the United States, where the incidence is growing at 8% annually (J.
tamponade secondary to Merkel cell carcinoma cardiae metastases.
Merck KGaA, Darmstadt, Germany, and Pfizer today announced that the US Food and Drug Administration (FDA) has granted avelumab, an investigational fully human anti-PD-L1 IgG1 monoclonal antibody, Breakthrough Therapy designation for the treatment of patients with metastatic Merkel cell carcinoma (MCC) who have progressed after at least one previous chemotherapy regimen.
To date, OncoSec's core immunotherapy platform, ImmunoPulse(TM), has been used to deliver DNA-based IL-12 in Phase II clinical trials for metastatic melanoma and Merkel cell carcinoma and plans to initiate Phase II studies in head and neck cancer and triple negative breast cancer.
Merkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma, which is an uncommon aggressive skin cancer, and trichodysplasia spinulosa-associated polyomavirus (TSPyV) is associated with trichodysplasia spinulosa, which is a rare skin disorder (1-3).
Merkel cell carcinoma (MCC) is an uncommon, aggressive cutaneous neoplasm with neuroendocrine differentiation, most commonly seen in the sunexposed skin of elderly, fair-skinned individuals.
Merkel cell carcinoma usually lacks the retraction artifact and has nuclei-speckled (salt-and-pepper) nuclear chromatin distribution.
Memorial donations may be made to the Merkel Cell Carcinoma Research Fund at the Dana Farber Institute, Attn: Dr.
OUR LUCAYA, BAHAMAS -- Merkel cell carcinoma is more deadly than melanoma and is almost always misdiagnosed clinically, Dr.