Merkel cell carcinoma

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Merkel cell carcinoma

[mer′kəl, mur′kəl]
Etymology: Friedrich S. Merkel, German anatomist and physiologist, 1845-1919
a rapidly growing malignant skin tumor that tends to occur on sun-exposed surfaces of older Caucasian individuals. It is composed of small cells in a trabecular pattern that contain dense core granules.
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Merkel cell carcinoma

Merkel cell carcinoma

A highly aggressive skin tumour, usually of the head and neck, which is most common in the elderly, and 13-fold more common in patients with HIV-1. Merkel cell polyomavirus is clonally integrated at various sites in the genome of most Merkel cell carcinomas.

Associations
Actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma.
 
DiffDx
Small blue-cell tumours—e.g., leukaemia, acute lymphoblastic lymphoma, granulocytic sarcoma, NK/T-cell lymphoma, and metastatic small cell carcinoma from the lung or elsewhere.
 
Prognosis
3-year survival: 68% female, 36% male.

Poor prognosticators
> 30 mm tumour, stage II+, lack of inflammation, Ki-67 (cell proliferation) index of > 50%.

Management
Wide excision, prophylactic lymph node dissection, radiation therapy, chemotherapy.

Merkel cell carcinoma

Cutaneous neuroendocrine carcinoma A highly malignant skin tumor, usually head & neck, most common in the elderly Prognosis Poor, 3-yr survival 68% ♀, 36% ♂ Treatment Wide excision, prophylactic LN dissection, RT, chemotherapy

Mer·kel cell car·ci·no·ma

(mĕr'kĕl sel kahr'si-nō'mă)
Rare and highly aggressive skin cancer, with lesions that develop on or just below the skin that are usually found on sun-exposed body areas; appear as painless, firm nodules or tumors; metastasize quickly and spread to other parts of the body, tending toward the regional lymph nodes. Twice as common in older men.
References in periodicals archive ?
Pathological and radiological differential diagnosis Small round blue cell tumour Radiological Non-Hodgkin's lymphoma Rhabdomyosarcoma Rhabdomyosarcoma Myosarcoma Small cell lung cancer Malignant fibrous Merkel cell cancer histiocytoma (MFH) Haemangiopericytoma Dedifferentiated liposarcoma Neuroblastoma Ewing's sarcoma Ewing's sarcoma Primitive neuro-ectodermal tumour (PNET)
Current outcomes to chemotherapy treatment have demonstrated short-lived responses with no clear impact on overall survival due to the 33% mortality rate inherent with Merkel cell cancer.
Contributions in James's memory can be given to Merkel Cell Cancer Research, by going to its website www.
Merkel cell cancer (MCC) is an aggressive cutaneous malignancy.
Although pioneered in the fields of skin and breast cancer, lymphatic mapping and sentinel lymph node biopsy have since been explored in Merkel cell cancer and cancers of the head and neck, stomach, colon, esophagus, anus, thyroid, penis, and vulva, Dr.
A patient with Merkel cell cancer had a complete response following treatment with huN901-DM1 and had been in remission for 21 months at the time of the conference.
Stephen Turner, Oncor's chairman and chief executive officer, said that the license covers any commercialization of the p58 findings including the manufacture and marketing of DNA probes of the diagnosis of malignant melanoma and neuroblastoma, a childhood brain tumor, as well as ductal breast cancer, Merkel cell cancer and endocrine neoplasia.
Additionally, huN901-DM1 showed evidence of anticancer activity, including one complete remission in a patient with recurrent Merkel cell cancer and marked tumor shrinkage in a patient with relapsed SCLC.
This patient was diagnosed with Merkel cell cancer in late 2003, underwent surgery, radiation therapy, and chemotherapy, but her cancer had reappeared by late 2004.