mephenesin


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mephenesin (mefen´isin),

n an antispasmodic drug, 3 ortho-toloxyl, 2 propanediol. Used for the preparation of apprehensive patients for dental and periodontal procedures because of its ability to produce muscular relaxation and euphoria. Usual dosage for an adult is 1 gm in either tablet or elixir form, 20 minutes before the dental procedure.

mephenesin

a centrally acting muscle relaxant. Once used in association with pentobarbital for anesthesia, but no longer used because of its many side-effects, including venous thrombosis and hemolysis.
References in periodicals archive ?
The second is mephenesin, which increases the resistance of the spinal cord to the passage through it of irritable stimuli.
Tenders are invited for Gel Of Mephenesin With Capsicum,Oleoresion And Nic.
9) reported that Mephenesin might be an antagonist of excitatory amino acids and might have NMDA-blocking activity and proposed that the NMDA-blocking activity of Mephenesin might be relevant to its muscle relaxing activity.
Specificity and potency of N-methyl-d-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Working on ways to preserve penicillin, Berger found that one of his compounds, mephenesin, had muscle-relaxant properties.
Despite aggressive treatment including breath-holding to interrupt the respiratory rhythm, continuous positive airway pressure, and medication with metoclopramine, prochlorperazine, chlorpromazine, haloperidol, mephenesin, diphenylhydantoin, baclofen, and phenobarbital, the hiccups persisted for 7 days.
Meyer HJ, Kretzschmar R (1966) Kawa pyrones: a new group of components in central muscle relaxing agents of the mephenesin type.
But a post-race drug test returned positive for the little-known drug mephenesin.
Jockey Club senior vet Keith Watkins confirmed that the drug used to dope Whytellyou was mephenesin, a muscle relaxant not commercially available in Hong Kong and which can, in some cases, cause death.
Whytellyou tested positive to the muscle relaxant, mephenesin, a prohibited substance.