Molecular characterization of Menangle virus
, a novel paramyxovirus which infects pigs, fruit bats and humans.
None of the 103 samples from Lae had antibodies against Menangle virus
Table 7-12 Less Common Zoonotic Paramyxoviruses Predominant Paramyxovirus Disease Signs in People Hendra virus Hendra virus Acute dyspnea, disease hemorrhagic First discovered disorders, and in 1994 in horses neurologic tissue in Brisbane, necrosis Australia (Hendra is a suburb of Brisbane) Menangle virus
Menangle Influenza-like First discovered in illness with a a swine operation macular rash; no in Menangle near fatalities reported Sydney in New South Wales, Australia in 1997.
The new virus, also a paramyxovirus, has been dubbed Menangle virus
(MenPV) was isolated in Australia during a disease outbreak in pigs, with epidemiologic evidence suggesting the involvement of human patients as a result of pig-to-human transmission (6).
For the final list of risk zoonoses, 3 of the original 30 agents (Hendra virus, Menangle virus
, and Rickettsia prowazekii) were removed because few, if any, genera were found to harbor these infections; the final tables therefore include 27 diseases (Tables 1--3).
Although closely related to Menangle virus
and associated with Pteropus spp.
Furthermore, 2 other paramyxo-oviruses belonging to the genus Rubulavirus have been associated with flying foxes: Menangle virus
, isolated in 1997 from pigs in Australia (13), and Tioman virus, isolated in 1999 from fruit bats in Malaysia (14).
was also described in Australia, in 1996, where it caused reproductive disorders in pigs and an influenzalike disease in humans.
The second virus, Menangle virus
, is considered to be spread to pigs in Australia by the same four species of Pteropus bats, producing stillbirths with deformities in 1998 in 27% of litters, as well as an influenza like illness in humans (30).
Tests performed at the Australian Animal Health Laboratory confirmed that the virus, named Menangle virus
, was unrelated to other known paramyxoviruses, including viruses known to infect pigs 51).