melittin


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mel·it·tin

(mel'i-tin),
The principal component in bee venom; melittin is a peptide amide containing 26 amino acyl residues and is a hemolysin.
[G. melitta, bee, + -in]

melittin

A 26-residue polypeptide which bears the toxic and haemolytic components of bee venom. It inhibits Ca2+/calmodulin-dependent protein kinase II, myosin light-chain kinase, Na+/K+-ATPase (synaptosomal membrane) and protein kinase C; it lyses cell membranes.

melittin

one of the toxic peptides in bee sting.
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A toxin in bee venom called melittin may be used to prevent the spread of HIV.
Drugs profiles discussed in this report includes ANG-3281, ANG-3298, ANG-4011, BGB-324, BOT-162, BOT-191, CC-539, CC-90001, CIGB-500, CT-140, DB-036, DCBBO-1202, disitertide, Drugs to Inhibit NADPH Oxidase for Influenza and Liver Fibrosis, F-351, FG-3019, GCS-100, GFT-505, GKT-137831, GKT-901, GM-CT-01, GM-CT-02, GR-MD-01, GR-MD-02, HepaStem, KW-0, LC-280126, LJPC-201, melittin, ND-L02s0201, NPLC-0393, P-17, PBI-4050, PRI-724, PRM-151, PXS-4728A, PXS-5033A, RXI-209, simtuzumab, Small Molecule for Liver Fibrosis, Small Molecule to Antagonize GPR91 for Retinal Angiogenesis and Liver Fibrosis, Stem Cell Therapy for Liver Fibrosis and Liver Diseases, Synthetic Peptide to Inhibit RSK for Fibrosis and Oncology, TCM-808FB, TGFTX-4 Program, VB-201, VBY-376, VBY-825.
The secondary metabolites were selected corresponding to the molecular targets to which they are directed, being different from those of melittin and the antibiotics.
The later contains a peptide known as melittin, which is known to increase blood circulation.
The particles locked onto HIV and delivered their cargo, the venom component melittin.
For example, approximately 85 alpha-haemolysin toxin produced by MRSA, 30 stretpolysin-O toxins and 850 melittin monomoers, which are part of bee venom.
The principal ingredient of bee venom, melittin, 'drills' a hole in the virus envelope, and disables it by essentially skinning it alive.
European hornet venom contains many pharmacologically active constituents including melittin, hyaluronidase, apamin, bradykinin, histamine, serotonin, dopamine, noradrenaline and phospholipase A (8).
Comparisons were made between melittin and erythromycin, tetracycline, penicillin, ampicillin, and vancomycin.
The melittin found in bee venom, for instance, has been shown to have anti-cancer properties.
Danger rating: 8/10 BEE (APIDAE) Description: Small flying creature which lives in colonies and produces honey Hazard: Bee stings contain venom which includes the toxin melittin and histamine which contribute to pain and itching.
The process uses nanoparticles to deliver the primary component of bee venom, called melittin, through the body to kill cancerous tumor cells.