MEIS1

(redirected from Meis1, myeloid ecotropic viral integration site 1 homolog)

MEIS1

A gene on chromosome 2p14 that encodes Meis homeobox 1, a homeobox protein belonging to the three amino acid loop extension (TALE) family of homeodomain-containing proteins. Meis homeobox 1 is a transcriptional regulator of PAX6 and transcriptional activator of PF4 when complexed with PBX1 or PBX2; it is required for hematopoiesis, megakaryocytopoiesis and vascular development.

Molecular pathology
Meis homeobox 1 may be a cofactor for HOXA7 and HOXA9 in inducing myeloid leukaemias.