meglitinide


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meglitinide

(meg-lit'in-id?)
Any of a class of oral agents used to treat type 2 diabetes mellitus, including nateglinide and repaglinide. Side effects include hypoglycemia and weight gain.
Synonym: glinide
References in periodicals archive ?
Meglitinide is another class of anti diabetic drug.
Tolbutamide and gliclazide block channels containing SUR1 ([beta]-cell type) but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide block both types of the channels [104].
The longitudinal retrospective analysis of a large administrative claims database found a 10% incidence of fracture on sulfonylureas and 11% on thiazolidinediones, compared with 7% on biguanides (metformin), 8% on dipeptidyl peptidase-4 (DPP-4) inhibitors, 11% on meglitinide analogues, and 6% on incretin mimetic agents.
9 mmol/l) in the first few hours after the start of fast, especially if insulin, sulphonylurea drugs or meglitinide are taken at Sehar.
Meglitinide analogues: a review of clinical data focused on recent trials.
Repaglinide is a meglitinide, similar to the sutphonylureas but with more rapid onset and shorter duration of action.
Successful combination of oral anti- hyperglycemic agents with their evidence- based recommendation for patients with type 2 diabetes, 2010 Combination Recommendation Metformin + Sulfonylurea A Metformin + Glitazone A Metformin + Acarbose B Metformin + Meglitinide B Sulfonylurea + Glitazone B Sulfonylurea + Acarbose B Gliptines + Metformin B Meglitinida + Glitazona B Source: ALAD Guidelines (6).
Repaglinide and nateglinide, which are meglitinide analogs, decrease ATP-sensitive [K.
Prandin, classified as a meglitinide, lowers blood glucose levels by stimulating the release of insulin from the pancreas and is dependent upon functioning beta cells in the pancreatic islets.
Insulin use and meglitinide use also resulted in statistically significant increases in the risk of diabetic macular edema (ME), the analysis found.