is another class of anti diabetic drug.
Tolbutamide and gliclazide block channels containing SUR1 ([beta]-cell type) but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide
block both types of the channels .
The longitudinal retrospective analysis of a large administrative claims database found a 10% incidence of fracture on sulfonylureas and 11% on thiazolidinediones, compared with 7% on biguanides (metformin), 8% on dipeptidyl peptidase-4 (DPP-4) inhibitors, 11% on meglitinide
analogues, and 6% on incretin mimetic agents.
9 mmol/l) in the first few hours after the start of fast, especially if insulin, sulphonylurea drugs or meglitinide
are taken at Sehar.
analogues: a review of clinical data focused on recent trials.
Repaglinide is a meglitinide
, similar to the sutphonylureas but with more rapid onset and shorter duration of action.
Successful combination of oral anti- hyperglycemic agents with their evidence- based recommendation for patients with type 2 diabetes, 2010 Combination Recommendation Metformin + Sulfonylurea A Metformin + Glitazone A Metformin + Acarbose B Metformin + Meglitinide
B Sulfonylurea + Glitazone B Sulfonylurea + Acarbose B Gliptines + Metformin B Meglitinida + Glitazona B Source: ALAD Guidelines (6).
Repaglinide and nateglinide, which are meglitinide
analogs, decrease ATP-sensitive [K.
Prandin, classified as a meglitinide
, lowers blood glucose levels by stimulating the release of insulin from the pancreas and is dependent upon functioning beta cells in the pancreatic islets.
analogues for type 2 diabetes mellitus.
Insulin use and meglitinide
use also resulted in statistically significant increases in the risk of diabetic macular edema (ME), the analysis found.
Should the patient have had surreptitious use of newer secretagogues such as repaglinide and meglitinide
, it would have required additional laboratory testing.