The longitudinal retrospective analysis of a large administrative claims database found a 10% incidence of fracture on sulfonylureas and 11% on thiazolidinediones, compared with 7% on biguanides (metformin), 8% on dipeptidyl peptidase-4 (DPP-4) inhibitors, 11% on meglitinide
analogues, and 6% on incretin mimetic agents.
Repaglinide is a meglitinide
, similar to the sutphonylureas but with more rapid onset and shorter duration of action.
Repaglinide and nateglinide, which are meglitinide
analogs, decrease ATP-sensitive [K.
Prandin, classified as a meglitinide
, lowers blood glucose levels by stimulating the release of insulin from the pancreas and is dependent upon functioning beta cells in the pancreatic islets.
Should the patient have had surreptitious use of newer secretagogues such as repaglinide and meglitinide
, it would have required additional laboratory testing.
Repaglinide (re-PAG-lyn-ide) is the name of a meglitinide
Among the patients receiving oral agents, 51% received a sulfonylurea, 22% received metformin, 21% received a thiazolidinedione, 4% received a meglitinide
, and 1% received acarbose.
Your doctor may prescribe lower doses of the sulfonylurea or meglitinide
Ayurvedic-Life's novel Gymnema sylvestre isolate has the ability to stimulate insulin secretion similar to sulphonylureas and meglitinide
analogues that are currently used for the treatment of Type 2 Diabetes.
PrandiMet([R]) is a meglitinide
and biguanide combination product indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are already treated with a meglitinide
and metformin HCl or who have inadequate glycemic control on a meglitinide
alone or metformin HCl alone.
PrandiMet[TM] has been approved to lower the blood glucose in adult patients with type 2 diabetes whose hyperglycemia cannot be controlled satisfactorily by meglitinide
Prandin[R] is an oral blood glucose-lowering drug of the meglitinide
class used in the management of Type 2 diabetes mellitus.