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megaloblast
(redirected from Megaloblasts)

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
megaloblast /meg·a·lo·blast/ (meg´ah-lo-blast″) a large, nucleated, immature progenitor of an abnormal erythrocytic series; the abnormal form corresponding to the normoblast.megaloblas´tic
meg·a·lo·blast (mg-l-blst)
n.
An abnormally large nucleated red blood cell found especially in pernicious anemia or in certain vitamin deficiencies.

mega·lo·blastic adj.

Megaloblast
A large erythroblast (a red marrow cell that synthesizes hemoglobin).
Mentioned in: Anemias

megaloblast
[meg′əlōblast′]
Etymology: Gk, megas + blastos, germ
an abnormally large nucleated immature erythrocyte that develops in large numbers in the bone marrow and is plentiful in the circulation in anemias associated with deficiency of vitamin B12, folic acid, or intrinsic factor. Effective treatment is the intramuscular injection of vitamin B12. megaloblastic, adj.

megaloblast [meg´ah-lo-blast″]
a large, nucleated immature progenitor of an abnormal erythrocytic series, an abnormal counterpart to the normoblast; megaloblasts are present in the blood in certain anemias. adj., adj megaloblas´tic.

megaloblast
a large, nucleated immature progenitor of an abnormal erythrocytic series; megaloblasts are present in the blood in certain anemias. These changes reflect asynchronism in maturation between cytoplasm and nucleus. Observed in folic acid responsive anemias.


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Deficiency of vitamin B12 can lead to the formation of abnormal cells called megaloblasts and result in anemia.
THE diagnosis requires blood tests to look for megaloblasts in your blood and possibly in your bone marrow too, and to measure your levels of vitamin B12 and folic acid.
Ehrlich distinguished 3 types of granulated white blood cells, as well as normoblasts, megaloblasts, and leukemic cells.
 
 
 
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