thrombopoietin

(redirected from Megakaryocyte Growth and Development Factor)
Also found in: Acronyms.

thrombopoietin

 [throm″bo-poi´ĕ-tin]
a colony-stimulating factor that is the humoral regulator of the production of platelets.

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin), [MIM*600044]
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
[thrombo- + G. poiētēs, maker, + in]

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin)
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
Synonym(s): megakaryocyte growth and development factor, megapoietin.
[thrombo- + G. poiētēs, maker, + in]

thrombopoietin

A hormone responsible for the growth of colonies of megakaryocytes and the production of platelets. The existence of thrombopoietin has been suspected for 30 years but was realized only in 1994. In 1997 the results of a trial of polyethylene-conjugated genetically-engineered (recombinant) thrombopoietin-described as recombinant human megakatyocyte growth and development factor (PEGrHuMGDF)-was published. It was found to have a powerful stimulatory effect on PLATELET production. Thrombopoietin is the ligand for the cytokine receptor Mpl.

thrombopoietin

an α2-globulin, a hormone involved in the differentiation and maturation of platelets but thought to be responsible for regulating the supply of platelets.
References in periodicals archive ?
BUSINESS WIRE)--April 27, 1995--Amgen (NASDAQ:AMGN) and Kirin Thursday announced that Amgen is beginning human clinical trials of its Megakaryocyte Growth and Development Factor (MGDF) product.