toxic megacolon

(redirected from Megacolon, toxic)

megacolon

 [meg″ah-ko´lon]
dilatation and hypertrophy of the colon.
Megacolon. From McKinney et al., 2000
acquired megacolon colonic enlargement associated with chronic constipation, but with normal ganglion cell innervation.
acute megacolon toxic megacolon.
aganglionic megacolon (congenital megacolon) Hirschsprung's disease.
toxic megacolon acute dilatation of the colon associated with amebic dysentery or ulcerative colitis; called also acute megacolon.

tox·ic meg·a·co·lon

acute nonobstructive dilation of the colon, seen in fulminating ulcerative colitis and Crohn disease.

toxic megacolon

Acute megacolon, toxic dilation of colon Gastroenterology A life-threatening complication of GI disease, resulting in transmural inflammation and toxic Sx due to colonic dilation Etiology ulcerative colitis, Crohn's disease, amebiasis, pseudomembranous colitis, typhoid, bacterial dysentery, Hirschsprung's disease Clinical Abdominal pain, distension, fever, tachycardia, fatigue, dehydration, ↓ bowel sounds, tympany, rebound tenderness, hypotension Contributing factors Laxatives, opiate use, anticholinergics, hypopotassemia Lab Leukocytosis–> 20,000/mm3, anemia, hypoalbuminemia, ↓ K+ Complications Perforation, peritonitis, septicemia Management Resuscitation, metabolic support, correct fluid and electrolyte derangements, corticosteroids, subtotal colectomy and ileostomy, salvage rectal sphincter if possible. Cf Megacolon.

tox·ic meg·a·co·lon

(tok'sik meg'ă-kō'lŏn)
Acute nonobstructive dilation of the colon, seen in fulminating ulcerative colitis and Crohn disease.

toxic megacolon

A gaseous ballooning or dilatation of the colon occurring as a complication of inflammatory bowel disease such as ulcerative colitis or Crohn's disease. The danger is of perforation which carries a high mortality. The condition can often be relieved by turning the patient into the prone position.

Toxic megacolon

Acute enlargement or dilation of the large intestine.

tox·ic meg·a·co·lon

(tok'sik meg'ă-kō'lŏn)
Acute nonobstructive dilation of the colon.