mebendazole (redirected from Mebendazol)

mebendazole /me·ben·da·zole/ (mĕ-ben´dah-zōl) an anthelmintic used against trichuriasis, enterobiasis, ascariasis, and hookworm disease.

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mebendazole

[məben′dəzōl]

an anthelmintic.

indications It is prescribed in treatment of pinworm, whipworm, roundworm, and hookworm infestations.

contraindications Pregnancy or known hypersensitivity to this drug prohibits its use.

adverse effects Among the most serious adverse effects are abdominal pain and diarrhea.

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mebendazole (mben´dzōl),

n an anthelmintic agent that acts against pathogenic roundworms by inhibiting their glucose intake and secretory processes.

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mebendazole

a broad-spectrum anthelmintic efficient against all gastrointestinal nematodes, lungworms and Moniezia in ruminants. It is not effective against Trichuris spp. and has reduced activity against benzimidazole-resistant worm species. It is not very effective against larval forms of Taenia spp., not effective against Draschia or Habronema spp. in horses, nor against Trichostrongylus axei. It is effective against Strongylus spp., but not against migrating Strongylus vulgaris larvae nor against Trichostrongylus axei, Strongyloides spp. or Anoplocephala perfoliata. It is recommended for general use in horses and combined with metriphonate for use against bot fly larvae. It is useful in dogs but does not remove Echinococcus granulosus or Dipylidium caninum. The drug has very low toxicity but has caused severe acute hepatic necrosis in some dogs.

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mebendazole

Boots Threadworm Tablets 2 Years Plus (UK), Ovex (UK), Pripsen (UK)

Pharmacologic class: Benzimidazole

Therapeutic class: Antihelmintic

Pregnancy risk category C

Action

Blocks glucose and other nutrient uptake in susceptible helminths, interfering with absorption

Availability

Tablets (chewable): 100 mg

⊘Indications and dosages

➣ Pinworm (Enterobius vermicularis)

Adults and children older than age 2: 100 mg P.O. as a single dose. Repeat in 2 to 3 weeks, if necessary.

➣ Whipworm (Trichuris trichiura), roundworm (Ascaris lumbricoides), American hookworm (Necator americanus), common hookworm (Ancylostoma duodenale), and mixed infections

Adults and children older than age 2: 100 mg P.O. in morning and evening for 3 days. Repeat in 3 weeks, if necessary.

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:
• impaired hepatic function, Crohn's ileitis, ulcerative colitis
• pregnant patients (use in first trimester only if benefit justifies risk to fetus)
• breastfeeding patients
• children younger than age 2.

Administration

• Know that tablets may be chewed, swallowed, or crushed and mixed with food.

Route	Onset	Peak	Duration
P.O.	Unknown	2-5 hr	Unknown

Adverse reactions

GI: abdominal pain, diarrhea

Other: fever

Interactions

Drug-drug. Carbamazepine, phenytoin: increased mebendazole metabolism and decreased efficacy (with high doses)

Cimetidine: inhibited mebendazole metabolism and increased blood level

Patient monitoring

• In prolonged therapy, monitor hematologic and hepatic studies.
• Ask family members if they have signs or symptoms of pinworm; infection spreads easily.

Patient teaching

• Tell patient he may chew tablets, swallow them whole, or crush and mix with food.
• Inform patient that parasite removal from GI tract may take up to 3 days after treatment. If he's not cured after 3 weeks, he may need a second course.
• Advise patient not to prepare food for others.
• Teach patient to maintain strict hygiene to prevent reinfection. Instruct him to disinfect bathroom daily and change and launder clothing, bed linens, and towels daily.
• Advise patient that dietary restrictions, fasting, and laxatives aren't necessary.
• Tell female patient to inform prescriber if she is pregnant or breastfeeding.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

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mebendazole

Vermox^® Parasitology A systemic anthelmintic that interferes with glucose metabolism, used to manage ascariasis–roundworms, enterobiasis, oxyuriasis–pinworms, trichuriasis–whipworms, uncinariasis–hookworm Adverse effects Fever, rash, itching, sore throat, asthenia. Cf Anthelmintic.