MDR1


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MDR1

Multi-drug-resistant protein No 1. see DRUG-TRANSPORTER GENES.
References in periodicals archive ?
Genetic variability and Haplotype profile of MDR1 in Roma and Hungarian population samples with a review of literature.
Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.
Comparison of our healthy subjects with Indian study from north India reveals that there was significant difference in the occurrence of GGH 401T, RFC1 80A and MDR1 1236T variant alleles.
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by downregulating MDR1 via a mechanism involving NF-kappa B signaling inhibition.
Genetic polymorphisms in CYP3A5, CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4), MDR1, UGT1A9, ABCC2 [ATPbinding cassette, sub-family C (CFTR/MRP), member 2; formerly known as MRP2], and TPMT (thiopurine S-methyltransferase) have an impact on tacrolimus, MPA, and azathioprine metabolism and transport, respectively.
The MDR1 gene encodes a major facilitator, the overexpression of which leads exclusively to fluconazole resistance (5,9,12).
The seven identified transporters are: the efflux transporters P-glycoprotein (P-gp, MDR1, ABCB1) and BCRP (ABCG2); organic cation transporter OCT2 (SLC22A2); organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC22A8); and organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3).
Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-kappaB signaling inhibition.
Tenders are invited for maintenance of road mdr3 to mdr1