McArdle's disease


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McArdle's disease

[məkär′dəlz]
Etymology: Brian McArdle, English neurologist, 1911-2002
an inherited glycolic storage disease marked by an absence of myophosphorylase B and abnormally large amounts of glycogen in skeletal muscle. It is milder than other glycogen storage diseases, characterized by muscle fatigability and stiffness after exercise. The only treatment is avoidance of exercise. Also called glycogen storage disease, type V. See also glycogen storage disease.

McArdle's disease

Glycogen storage disease V Metabolic disease An AR condition caused by muscle phosphorylase deficiency Clinical Exercise intolerance, premature fatigue, myalgia, and cramping

McArdle's disease

An autosomal recessive disorder of muscle carbohydrate metabolism in which glycogen breakdown is blocked because of non-functioning of the enzyme myophosphorylase. The effect is a considerable reduction in exercise capacity. Attempts at strenuous activity cause cramps, muscle injury, RHABDOMYOLYSIS and MYOGLOBINURIA. Ingestion of sucrose before exertion can markedly improve exercise capacity.