Mayo Risk Score

Mayo Risk Score

A decision-making model for primary biliary cirrhosis and primary sclerosing cholangitis based on five variables—three lab parameters (serum BR levels, serum albumin levels and prothrombin time), patient age and severity of oedema and/or ascites—which allows prognostication. The Mayo Risk Score provides accurate information about the patient’s prognosis.

The Mayo Risk Score
(R)   =   (0.0295 * (age in years))
          + (0.5373 * LN(total bilirubin in mg/dL))
          – (0.8389 * (serum albumin in g/dL))
          + (0.5380 * LN(AST in IU/L)
          + (1.2426 * (points for variceal bleeding))
where:
LN indicates the natural logarithm; and
AST = serum aspartate aminotransferase level.

Points for variceal bleeding: 0 if none, 1 if present. Each unit increase in the Mayo Risk Score (R) is associated with a 2.5-fold increase in the risk of death; most references to the score round the coefficients to 2 decimal places.

The score shows very slight upward slope over time in stable patients, but during the terminal phase it shows an acceleration in progression.
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