May-Hegglin anomaly

anomaly /anom·a·ly/ (ah-nom´ah-le) marked deviation from normal, especially as a result of congenital or hereditary defects.anom´alous

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Alder's anomaly  an autosomal dominant condition in which leukocytes of the myelocytic series, and sometimes all leukocytes, contain coarse azurophilic granules.

Chédiak-Higashi anomaly  see under syndrome.

congenital anomaly  a developmental anomaly present at birth.

developmental anomaly 

1. a structural abnormality of any type.

2. a defect resulting from imperfect embryonic development.

Ebstein's anomaly  a malformation of the tricuspid valve, usually associated with an atrial septal defect.

Ebstein's anomaly, showing displacement of the septal and posterior leaflets of the tricuspid valve into the right ventricle and accompanied by a patent foramen ovale.

May-Hegglin anomaly  an autosomal dominant disorder of blood cell morphology, characterized by RNA-containing cytoplasmic inclusions (similar to Döhle bodies) in granulocytes, by large, poorly granulated platelets, and by thrombocytopenia.

Pelger's nuclear anomaly  Pelger-Huët nuclear a. (1).

Pelger-Huët nuclear anomaly 

1. a hereditary or acquired defect in which the nuclei of neutrophils and eosinophils appear rodlike, spherical, or dumbbell-shaped; the nuclear structure is coarse and lumpy.

2. an acquired condition with similar features, occurring in certain anemias and leukemias.

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May-Hegglin anomaly (m-)

n.

See Hegglin's anomaly.

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May-Hegglin anomaly,

a rare autosomal-dominant inherited blood cell disorder characterized by thrombocytopenia and granulocytes with blue-colored ribonucleic acid containing cytopathic inclusions similar to Döhle's bodies.

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anomaly [ah-nom´ah-le]

marked deviation from normal. adj., adj anom´alous.

Axenfeld's anomaly a developmental anomaly characterized by a circular opacity of the posterior peripheral cornea, and caused by an irregularly thickened, axially displaced Schwalbe's ring.

congenital anomaly (developmental anomaly) absence, deformity, or excess of body parts as the result of faulty development of the embryo.

Ebstein's anomaly see ebstein's anomaly.

May-Hegglin anomaly a rare dominantly inherited disorder of blood cell morphology, characterized by RNA-containing cytoplasmic inclusions (similar to Döhle bodies) in granulocytes, by large, poorly granulated platelets, and by thrombocytopenia.

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May-Hegglin anomaly

Hematology A rare AD condition characterized by the triad of thrombocytopenia, giant platelets, and Döhle-body-like inclusions in WBC cytoplasm Clinical Recurrent epistaxis, gingival bleeding, easy bruising, menorrhagia, excess bleeding postsurgery Management Most Pts are asymptomatic; corticosteroids, splenectomy are useless; platelet transfusions may be needed. See Hereditary thrombocytopenia.