MMP7

(redirected from Matrix metalloproteinase-7)

MMP7

A gene on chromosome 11q21-q22 that encodes matrix metalloproteinase 7, which degrades proteoglycans, fibronectin, elastin and casein and activates procollagenase. It is involved in breaking down the extracellular matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members as it lacks a conserved C-terminal protein domain.
 
Molecular pathology
Defects in MMP7 have been linked to arthritis and metastasis.
References in periodicals archive ?
Matrix metalloproteinase-7 mediated cleveage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity.
Expression of Matrix Metalloproteinase-7 on Cancer Cells and Tissue Endothelial Cells in Renal Cell Carcinoma: Prognostic Implications and Clinical Significance for Invasion and Metastasis.
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Expression of matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-1 in human prostate.
Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.
Development of in situ zymography to localize active matrix metalloproteinase-7 (matrilysin-1).
Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas.
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand.
Matrix metalloproteinase-7 (MMP-7), a zinc- and calcium-dependent endopeptidase, is 1 of these 12 candidate proteins.
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival.
A multiplexed particle-based flow cytometric assay identified plasma matrix metalloproteinase-7 to be associated with cancer-related death among patients with bladder cancer.
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