MMP7

(redirected from Matrix metalloproteinase-7)

MMP7

A gene on chromosome 11q21-q22 that encodes matrix metalloproteinase 7, which degrades proteoglycans, fibronectin, elastin and casein and activates procollagenase. It is involved in breaking down the extracellular matrix in physiological processes—e.g., embryonic development, reproduction, tissue remodelling and wound healing. It differs from most MMP family members as it lacks a conserved C-terminal protein domain.
 
Molecular pathology
Defects in MMP7 have been linked to arthritis and metastasis.
References in periodicals archive ?
DNA microarray analysis also demonstrated that PTE significantly down-regulates the expression of KRAS, a tissue signaling protein that acts as an "on switch" for cancer cell propagation, as well as matrix metalloproteinase-7 (MMP-7), an enzyme involved in physiological functions and disease progression such as cancer metastasis.
Matrix metalloproteinase-7 facilitates insulin-like growth factor bioavailability through its proteinase activity on insulin-like growth factor binding protein 3.
Development of in situ zymography to localize active matrix metalloproteinase-7 (matrilysin-1).
Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas.
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand.
Matrix metalloproteinase-7 (MMP-7), a zinc- and calcium-dependent endopeptidase, is 1 of these 12 candidate proteins.
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival.
Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis.
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