MMP1

(redirected from Matrix metalloproteinase-1)

MMP1

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 1, which cleaves collagens I, II and III in the helical domain, as well as collagens VII and X. MMP1 interacts and cleaves HIV’s secreted Tat protein, reducing neuronal Tat-mediated neurotoxicity.
References in periodicals archive ?
3,16) To make matters worse, ultraviolet (UV) exposure (21,22) and AGE formation (1) itself generate free radicals that further exacerbate this problem by increasing activity of the collagen-degrading enzyme matrix metalloproteinase-1 (MMP-1).
Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke.
DEP evokes the secretion of matrix metalloproteinase-1 (MMP-1) from human bronchial epithelia, which is important because MMP-1 plays a role in tissue remodeling during respiratory disease processes.
Matrix metalloproteinase-1 (MMP-1) is a collagenase (it is also called 'interstitial collagenase') that acts on native (i.
The study examined the question of, if by damaging DNA with reactive oxygen species (ROS) would there be an increase of either/both matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor, two factors known to play roles in photoaging.
Dr Griffiths said that smoking enhanced an enzyme in the skin called matrix metalloproteinase-1.
Scientists at Louisiana State University have demonstrated the in-vitro inhibitory activity of the Bowman-Birk inhibitor from soybean and rice, ellagic acid from grapes, black bean tannins, thymoquinone from black seeds, purpurin, and phytic from cereals and legumes against angiogenesis stimulators such as the matrix metalloproteinase-1, -2, and -9, and cancer cell proliferation.
For genotyping, we used previously published primer sets and PCR conditions for the matrix metalloproteinase-1 (MMP1) (2), matrix metalloproteinase-3 (MMP3) (3), and plasminogen activator inhibitor-1 (PAI-1) (3) genes.
Recent work suggests that fetal genetic factors, which predispose to the production of matrix-degrading enzymes such as matrix metalloproteinase-1 and -9, may be important in determining the likelihood of preterm PROM," Dr.
Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking between fibroblasts and U937 macrophages exposed to high glucose.
Matrix metalloproteinase-1 (MMP-1) has been implied as an (etio) pathogenic factor in human lung and airway diseases such as emphysema, chronic obstructive pulmonary disease, chronic asthma, tuberculosis, and bronchial carcinoma and has been reported to be regulated by DEPs,

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