matrix metalloproteinase

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matrix metalloproteinase

endopeptidase subfamily that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.

matrix metalloproteinase

any of a group of endopeptidases that hydrolyze proteins of the extracellular matrix.

matrix metalloproteinase

A family of 25 zinc-dependent extracellular endopeptidases, which differ widely in substrate preferences (e.g., collagens, elastins, proteoglycans). MMPs are often present in disease and development; they are critical to tissue remodeling and expressed in certain malignancies, intimately linked to invasion and metastasis, an activity which is specifically blocked by tissue inhibitors of metalloproteinases (TIMPs). MMPs are also linked to tissue damage in interstitial lung disease, diffuse alveolar damage, and pulmonary lymphangioleiomyomatosis. MMPs are either secreted or membrane-bound (MT-MMPs) and anchored to the cell membrane by transmembrane and intracytoplasmic domains.

Matrix metalloproteinases
• Collagenases—digest triple-helical fibrillar collagens, major components of bone and cartilage. Members: MMP-1, MMP-8, MMP-13, MMP-18, MMP-14, MMP-2 (list differs from MESH, see there).

• Gelatinases—Digest type IV collagen and gelatin. Members: MMP-2, MMP-9.

• Stromelysins—Digest extracellular matrix proteins but not triple-helical collagens. Members: MMP-3, MMP-10, MMP-11.

• Membrane-type MMPs have a furin cleavage site (which is also seen in MMP-11, a stromelysin). Members: MMP-14 to MMP-17, MMP-24, MMP-25.

ma·trix me·tal·lo·pro·tein·ase

(mā'triksmĕ-tal'ō-prō'tē-nās)
A subfamily of endopeptidases that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
References in periodicals archive ?
Patients who reached success at 12 weeks were those who started with lower baseline levels of matrix metalloprotease, or lower or intermediate baseline levels of serine protease," Dr.
As stated, a number of disease states involve overexpression of matrix metalloproteases, and there exist diseases in which mutations result in overexpression of MMP-13 and premature development of osteoarthritis.
It has also been shown that membrane type 1 matrix metalloproteases are modifying the laminin-rich basal membrane, playing thus a role in transformation of prostate intraepithelial neoplasm into invasive cancer through their capacity to degrade laminin [39, 51,52].
Distinct roles of matrix metalloproteases in the early and late-phase development of neuropathic pain.
Biologically Important Metalloenzymes for Skin Anti-aging Metalloenzyme Function Metal Tyrosinase Tyrosine oxidation Cu, Zn Superoxide Dismutase Superoxide detoxification Cu, Zn, Mn Catalase Peroxide decomposition Fe Matrix Metalloproteases Protein hydrolysis Zn Dopamine Hydroxylase Dopamine conversion Cu Amine Oxidase Elastin, collagen synthesis Cu Cytochrome Oxidase Oxidation Cu Ceruplasmin Oxidation Cu Glutathione Peroxidase Peroxide detoxification Se Glucose Tolerance Factor Glucose metabolism Cr
New Matrix Metalloprotease (MMP) inhibitors and their application in cosmetic and OTC drug formulations, PCITX Conference, New York, NY, April 26, 2005
Schultz (the University of Florida at Gainesville), summarizes research that demonstrates the Company's Ilomastat technology, a powerful matrix metalloprotease inhibitor, can suppress the primary blistering damage mechanism in a human tissue explant model after exposure to sulfur mustard, even when treatment occurred hours after exposure.
and Aventis have entered into an agreement to advance the identification, discovery and validation of highly selective, orally available matrix metalloprotease (MMP) inhibitors, a promising new class of drugs for treatment of a broad array of pathologies involving the extracellular matrix.
Further molecular analyses demonstrated that IMMUNITIN down-regulates inflammatory mediator genes, including Interleukin 1(beta) gene (IL-1(beta)), Interleukin 6 gene (IL-6), Macrophage Chemotactic Protein 1 gene (MCP1), inducible-Nitric Oxide Synthase gene (iNOS), responsible for the generation of nitric oxide (NO), and Matrix Metalloprotease 9 gene (MMP9), involved in tissue destruction and bone remodeling.
Physiology and pathophysiology of matrix metalloproteases.
Some of extensively studied CAPs include urokinase plasminogen activator (uPA), matrix metalloproteases (MMPs) and some of the cathepsins (8).

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