matrix metalloproteinase

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matrix metalloproteinase

endopeptidase subfamily that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.

matrix metalloproteinase

any of a group of endopeptidases that hydrolyze proteins of the extracellular matrix.

matrix metalloproteinase

A family of 25 zinc-dependent extracellular endopeptidases, which differ widely in substrate preferences (e.g., collagens, elastins, proteoglycans). MMPs are often present in disease and development; they are critical to tissue remodeling and expressed in certain malignancies, intimately linked to invasion and metastasis, an activity which is specifically blocked by tissue inhibitors of metalloproteinases (TIMPs). MMPs are also linked to tissue damage in interstitial lung disease, diffuse alveolar damage, and pulmonary lymphangioleiomyomatosis. MMPs are either secreted or membrane-bound (MT-MMPs) and anchored to the cell membrane by transmembrane and intracytoplasmic domains.

Matrix metalloproteinases
• Collagenases—digest triple-helical fibrillar collagens, major components of bone and cartilage. Members: MMP-1, MMP-8, MMP-13, MMP-18, MMP-14, MMP-2 (list differs from MESH, see there).

• Gelatinases—Digest type IV collagen and gelatin. Members: MMP-2, MMP-9.

• Stromelysins—Digest extracellular matrix proteins but not triple-helical collagens. Members: MMP-3, MMP-10, MMP-11.

• Membrane-type MMPs have a furin cleavage site (which is also seen in MMP-11, a stromelysin). Members: MMP-14 to MMP-17, MMP-24, MMP-25.

ma·trix me·tal·lo·pro·tein·ase

(mā'triksmĕ-tal'ō-prō'tē-nās)
A subfamily of endopeptidases that hydrolyze extracellular proteins, especially collagens and elastin. By regulating the integrity and composition of the extracellular matrix, these enzymes play a pivotal role in the control of signals elicited by matrix molecules that regulate cell proliferation, differentiation, and death.
References in periodicals archive ?
Other "targeted therapies" such as matrix metalloprotease inhibitors, inhibitors of angiogenesis, anti-EGFR antibodies or farnesyltransferasein-hibitors failed in large phase III trials.
CTS-1027 is a first-in-class oral, small molecule inhibitor of host matrix metalloprotease (MMP) activity.
8:02 Matrix Metalloprotease Activity Is Increased in Obese Dog Kidneys
AG3340, a matrix metalloprotease inhibitor demonstrating potent anti-angiogenic and anti-metastatic properties is in Phase III clinical trials in combination with the anticancer drugs paclitaxcl/carboplatin for the proposed treatment of non-small cell lung cancer, and with mitoxantrone/prednisone for the proposed treatment of hormone-refractory prostate cancer.
Of these, tyrosinase, superoxide dismutase, calalase, matrix metalloprotease, and glutathione peroxidase are most important from skin anti-aging point of view.
XL784 is a potent inhibitor of the ADAM-10 matrix metalloprotease (MMP) enzyme that plays an important role in blood vessel formation and cell proliferation.
Mechanical stress induces matrix metalloprotease expression in the skin.
Schultz (the University of Florida at Gainesville), summarizes research that demonstrates the Company's Ilomastat technology, a powerful matrix metalloprotease inhibitor, can suppress the primary blistering damage mechanism in a human tissue explant model after exposure to sulfur mustard, even when treatment occurred hours after exposure.
Pfizer (NYSE: PFE) announced today that preliminary results of phase III clinical trials of prinomastat, a matrix metalloprotease inhibitor (MMPI), in advanced hormone refractory prostate cancer and advanced (Stage IV) non-small cell lung cancer did not meet primary efficacy objectives.
and Aventis have entered into an agreement to advance the identification, discovery and validation of highly selective, orally available matrix metalloprotease (MMP) inhibitors, a promising new class of drugs for treatment of a broad array of pathologies involving the extracellular matrix.

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