We believe that Mast Cell
Connect will contribute to better care for people with mastocytosis by systematically documenting the impact and natural history of this rare disease and increasing participation in clinical studies.
Since then, this condition has evolved to include a number of mast cell
activation disorders associated with acute coronary syndrome.
Antibody formation, attachment of antibody (IgE) to the mast cell
, and antigen-antibody union are not prevented by cromolyn.
Peritoneal mast cells
were easily identified by the presence of a cytoplasm dominated by distinctive secretory granules which stain metachromatically (Fig.
Bone marrow biopsy 14 days after induction of treatment revealed persistent myeloblasts and mast cell
infiltrate requiring a second course of therapy with 5 days of high-dose Ara-C (1 g/[m.
Activated mast cells
increase the level of endothelin-1 mRNA in co-cultured endothelial cells and degrade the secreted peptide.
Some people may also have a polymorphism of the genes for their IgE receptors on the mast cell
, which causes greater than normal responses by mast cells
to the binding of IgE.
When the researchers studied blood serum samples from patients with dengue infection, they found that the levels of a protein produced by mast cells
, chymase, were significantly higher in the patients who developed dengue hemorrhagic fever compared to those who recovered after dengue fever.
Combination therapy typically involves antihistamines to block the histamine released from mast cells
and basophils, LTRAs (leukotriene receptor antagonists) to block leukotrienes, and nasal corticosteroids to block the various inflammatory mediators that participate in allergic reactions.
In cases of SM, hematoxylin-eosin-stained bone marrow biopsy sections demonstrate multifocal or diffuse cohesive infiltrates of mast cells
with spindle-shaped morphology or other atypical morphologic features, including immature chromatin or nuclear lobation/multinucleation.
In a comparison of histamine release by morphine, fentanyl and oxymorphone from human skin mast cells
(66), release was first detected with morphine at 1.
A commercial Romanowsky stain (Diff-Quik, Jorgensen Laboratories Inc, Loveland, CO, USA) applied to the tissue sample revealed a highly cellular infiltrate composed primarily of presumptive mast cells
and background erythrocytes (Fig 2A).