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Marek's disease

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Marek's disease
a transmissible disease of chickens caused by an alphaherpesvirus that carries some retrovirus oncogenes; characterized by a tumorous, mononuclear infiltration of peripheral nerves, causing limb paralysis. Infiltration of other organs and tissues is common, especially of the iris, causing blindness, and of the ovaries. Vaccination is highly effective and without it serious outbreaks with heavy losses can occur. Called also neural lymphomatosis, neurolymphomatosis gallinarum.


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Based on a serologic survey to assess exposure to avian pathogens, birds (n = 69) were seronegative for West Nile virus, avian paramyxovirus type 1 (Newcastle disease virus), avian paramyxovirus types 2 and 3, avian influenza, infectious bursal disease, infectious bronchitis, Marek's disease (herpes), reovirus, avian encephalomyelitis, and avian adenovirus type 2.
Coussens conducted research on the molecular biology of Marek's disease virus, an oncogenic alpha-herpesvirus.
Several novel criteria have been tested to assist in the differential diagnosis of tumors induced by Marek's disease virus (MDV) from those induced by avian leukosis virus (ALV) and reticuloendotheliosis virus (REV).
 
 
 
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