Marchiafava-Bignami diseaseA condition that occurs in chronic alcoholics, clinically characterised by progressive neurological disease and histologically characterised by corpus callosum demyelination, necrosis and atrophy.
[E. Marchiafava, It. pathologist, 1847–1935; A. Bignami, It. physician, 1862–1929]
Damage to the white matter of the brain, with dementia, resulting from chronic alcoholism, esp. excessive wine consumption.