maprotiline


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maprotiline

 [mah-pro´tĭ-lēn]
a tetracyclic antidepressant administered orally as the hydrochloride salt for relief of symptoms of depression. It acts by blocking the reuptake of norepinephrine at nerve terminals; unlike tricyclic antidepressants, it has no effect on serotoninergic transmission.

maprotiline

/ma·pro·ti·line/ (mah-pro´tĭ-lēn) a tetracyclic antidepressant with actions similar to those of the tricyclic antidepressants; used as the hydrochloride salt.

maprotiline

A tetracyclic antidepressant similar to tricyclic agents.
 
Indications
Major depression, bipolar disorder.

Adverse effects
Anticholinergic effects (e.g., dizziness, drowsiness, fatigue, dry mouth), orthostatic hypotension, sinus tachycardia or other arrhythmias, sexual dysfunction, rash, photosensitivity, confusion, seizures, liver toxicity, agranulocytosis, polyneuritis and other findings.

Special considerations
Should not be administered with MAOIs; may be toxic to the liver or kidneys; may cause seizures; may cause arrhythmias or heart failure.

maprotiline

Ludiomil® Neuropharmacology A tetracyclic antidepressant similar to tricyclic agents Indications Major depression, bipolar disorder. See Tricyclic antidepressant.
References in periodicals archive ?
20%) Co-administration can cause Maprotiline prolongation of the QT interval, and may result in elevated risk of ventricular arrhythmias including ventricular tachycardia and torsade de pointes *Drug-Drug interaction; **This is based on Lexi-comp 201314 Table 4: Logistic Regression Analyzes of DDI * Data Variables Categorial Odds 95% confidence Level ratio interval for odds ratio Lower Upper 15-30 Reference -- -- 31-45 0.
The potential risk of fracture presented by class of psychotropic medications Class of drug Lowest risk Moderate risk Highest risk Anticonvulsants Lamotrigine Carbamazepine Phenytoin Valproic acid Antidepressants Maprotiline Amitriptyline Citalopram Mirtazapine Desipramine Fluoxetine Tranylcypromine Doxepin Fluvoxamine Nefazodone Imipramine Nortriptyline Paroxetine Trazodone Sertraline Venlafaxine Antipsychotics Aripiprazole lloperidone Haloperidol Asenapine Lurasidone Paliperidone Clozapine Olanzapine Risperidone Quetiapine Typical Ziprasidone antipsychotics (all) Lithium May be protective but evidence is insufficient
35) Development of bilateral ACG was stated in a 71-year-old patient using maprotiline and alprazolam.
Additionally anti-inflammatory effect of amitriptyline [20], fluvoxamine [21], and maprotiline [22] on carrageenan-induced paw edema has been evaluated in our laboratory.
Antidepressant drugs, including Tricyclic Antidepressant (TCAs), Selective serotonin reptake Inhibitors (SSRIs), Monoamine Oxidase Inhibitors (MAOIs), maprotiline, trazodone, Bupropion and venlafaxine.
These drugs include bupropion (Wellbutrin, Wellbutrin SR, Zyban), trazodone (Desyrel), maprotiline (Ludiomil) and mirtazapine (Remeron).
Maprotiline hydrochloride tablets (Novartis, Beijing, China), Anafranil (clomipramine hydrochloride tablets, Novartis, Beijing, China), Seroxat (paroxetine hydrochloride tablets, SmithKline, Tianjin, China), Prozac (fluoxetine hydrochloride capsules, Patheon, Bourgoin-Jallieu, France), and Neurostan (extract of St.
Dan zhi xiao yao, a traditional Chinese medicine, was as effective as the tricyclic antidepressant maprotiline in 1 small RCT.
A large, Canadian case-control study published in 2002 raised concerns of heightened cancer risk among patients prescribed certain tricyclic antidepressants (amoxapine, clomipramine, desipramine, doxepin, imipramine, and trimipramine) but not others (amitriptyline, maprotiline, nortriptyline, protriptyline) (Br.
The medications were classified as selective serotonin reuptake inhibitors (SSRIs) (citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline); serotonin norepinephrine reuptake inhibitors (venlafaxine); tricyclics (amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, maprotiline, nortriptyline, protriptyline, and trimipramine); newer and atypical agents (mirtazapine, nefazodone, and trazodone); and monoamine oxidase inhibitors (moclobemide, phenelzine, and tranylcypromine).
in urine 36 Prothipendyl 2275 2618 41 Fluoxetine 4338 4278 Bromazepam 129 Maprotiline 352 349 50 Caffeine 191 Ketamine 1050 Bisacodyl 106 1750 58 Paracetamol 825 188 Diazepam 272 60 Amphetamine 55 68 Venlafaxine 5269 69 Prothipendyl 387 1883 76 Sertraline 4642 4640 4685 81 Metformine 6510 Dobutamine 1273 2980 83 Midazolam 296 90 Maprotiline 348 352 349 Sample Substance Name of detected compound no.