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a tuberculin skin test in which a solution of 0.1 mL of PPD-tuberculin containing 5 tuberculin units is injected intradermally into either the anterior or posterior surface of the forearm. The test is read 48 to 72 hours after injection. The size of the area of any induration at the site of injection, in combination with patient risk factors, is used to determine whether the test is positive, that is, whether exposure to or infection with Mycobacterium tuberculosis (the agent causing tuberculosis) or a related organism has occurred.
application of the skin test to the diagnosis of infection by Mycobacterium tuberculosis in which tuberculin or its "purified" protein derivative serves as an antigen (allergen); injection of graduated doses of tuberculin or of purified protein derivative into the skin, most often by means of a needle and syringe (Mantoux test) or by means of tines (tine test); test material may also be applied by means of a "patch" in which it is absorbed but this method (patch test) is considered less reliable; the test is read on the basis of induration and erythema, the former being considered the more diagnostic of infection with the tubercle bacillus (M. tuberculosis); the test does not distinguish between infection in a resistant person without disease and a person with clinical manifestations of disease.
Mantoux test(măn-to͞o′, män-)
A tuberculin test in which a small amount of tuberculin is injected under the skin.
Etymology: Charles Mantoux, French physician, 1877-1947
a tuberculin skin test that consists of intradermal injection of a purified protein derivative of the tubercle bacillus. A hardened, raised red area of 8 to 10 mm, appearing 24 to 72 hours after injection, is a positive reaction. This method is the most reliable means of testing tuberculin sensitivity. See also tuberculin test.
Mantoux testAn intracutaneous test used to diagnose TB based on hypersensitivity to tuberculin, a concentrate of TB antigen, the standard preparation of which is purified protein derivative.
Mantoux testMantoux tuberculin skin test An intracutaneous test used to diagnose TB based on hypersensitivity to tuberculin, a concentrate of TB antigen, the standard preparation of which is PPD–purified protein derivative. See PPD, Tuberculin test, Tuberculosis.
tu·ber·cu·lin test(tū-bĕr'kyū-lin test)
A dermatologic procedure in which tuberculin or its purified protein derivative (PPD) is injected into the skin; the test is read on the basis of local induration occurring in 48-72 hours.
Mantoux testA skin test for resistance to TUBERCULOSIS in which a small quantity of a sterile liquid derived from a culture of tubercle bacilli (tuberculin) is injected into the skin and the local reaction noted. A negative result suggests susceptibility to tuberculosis and may prompt vaccination with BCG. The test is now performed by a rapid multiple puncture technique, similar to the Heaf test, but using disposable, multiple-tine test units. (Charles Mantoux, 1887–1947, French physician).
a tuberculin skin test used in humans to detect prior exposure to Mycobacterium spp.