Mantoux test


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Mantoux test

 [man-too´]
a tuberculin skin test in which a solution of 0.1 mL of PPD-tuberculin containing 5 tuberculin units is injected intradermally into either the anterior or posterior surface of the forearm. The test is read 48 to 72 hours after injection. The size of the area of any induration at the site of injection, in combination with patient risk factors, is used to determine whether the test is positive, that is, whether exposure to or infection with Mycobacterium tuberculosis (the agent causing tuberculosis) or a related organism has occurred.

tu·ber·cu·lin test

application of the skin test to the diagnosis of infection by Mycobacterium tuberculosis in which tuberculin or its "purified" protein derivative serves as an antigen (allergen); injection of graduated doses of tuberculin or of purified protein derivative into the skin, most often by means of a needle and syringe (Mantoux test) or by means of tines (tine test); test material may also be applied by means of a "patch" in which it is absorbed but this method (patch test) is considered less reliable; the test is read on the basis of induration and erythema, the former being considered the more diagnostic of infection with the tubercle bacillus (M. tuberculosis); the test does not distinguish between infection in a resistant person without disease and a person with clinical manifestations of disease.

Mantoux test

(măn-to͞o′, män-)
n.
A tuberculin test in which a small amount of tuberculin is injected under the skin.

Mantoux test

[manto̅o̅′]
Etymology: Charles Mantoux, French physician, 1877-1947
a tuberculin skin test that consists of intradermal injection of a purified protein derivative of the tubercle bacillus. A hardened, raised red area of 8 to 10 mm, appearing 24 to 72 hours after injection, is a positive reaction. This method is the most reliable means of testing tuberculin sensitivity. See also tuberculin test.
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Positive Mantoux test

Mantoux test

An intracutaneous test used to diagnose TB based on hypersensitivity to tuberculin, a concentrate of TB antigen, the standard preparation of which is purified protein derivative.

Mantoux test

Mantoux tuberculin skin test An intracutaneous test used to diagnose TB based on hypersensitivity to tuberculin, a concentrate of TB antigen, the standard preparation of which is PPD–purified protein derivative. See PPD, Tuberculin test, Tuberculosis.

tu·ber·cu·lin test

(tū-bĕr'kyū-lin test)
A dermatologic procedure in which tuberculin or its purified protein derivative (PPD) is injected into the skin; the test is read on the basis of local induration occurring in 48-72 hours.

Mantoux test

A skin test for resistance to TUBERCULOSIS in which a small quantity of a sterile liquid derived from a culture of tubercle bacilli (tuberculin) is injected into the skin and the local reaction noted. A negative result suggests susceptibility to tuberculosis and may prompt vaccination with BCG. The test is now performed by a rapid multiple puncture technique, similar to the Heaf test, but using disposable, multiple-tine test units. (Charles Mantoux, 1887–1947, French physician).

Mantoux test

a tuberculin skin test used in humans to detect prior exposure to Mycobacterium spp.
References in periodicals archive ?
A comparison of the extent of cutaneous reaction in the Mantoux test with the results of the in vitro assay (Graph 1-2) shows that the greater the diameter of induration the higher the possibility of finding effector T-cells secreting [gamma]-interferon.
There is depression of cutaneous delayed type hypersensitivity as demonstrated by a negative Mantoux test and heightened helper T-cell type response at the sites of the disease.
It is not uncommon to find that treatment has been started just on the basis of positive Mantoux test.
Dated 23 to 27 May, 2009: Pleural biopsy was inconclusive; Mass was seen in USG of the thorax; Mantoux test, FNAC and CT investigations were not consented.
Presence of multinucleated giant cells in the histopathology prompted for ruling out tuberculosis and deep fungal infection,hence Mantoux test, bacterial PCR, special staining with Grocott-Gomori methenamine-silver nitrate and PAS were performed.
But the Mantoux test does not allow precise diagnosis, only indicates that the patient has had previous contact with Mycobacterium tuberculosis, and can lead to false negative results in case of anergy [7].
Fine-needle aspiration cytology of the lymph nodes was suggestive of tuberculosis, and the Mantoux test was strongly positive.
The Mantoux test, performed with 10 IU of purified tuberculin (Aventis-Pasteur-MSD, Lyon, France), yielded a maximum transverse diameter of induration of 15 mm.
For example, although the Mantoux test has an overall sensitivity and specificity of 95%, the positive predictive value is only 15% if the prevalence of infection is 1%, yielding a false-positive rate of 85%.
Anyone entering a Los Angeles County school for the first time is required to show proof of an appropriate TB screening, such as the Mantoux test.