mannan-binding lectin

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mannan-binding lectin (MBL),

a circulating plasma, acute phase protein of hepatic origins that plays an important role in the innate immune response to infection, because it binds to carbohydrates on bacteria, and subsequently activates the complement pathway. It is a key feature in the lectin pathway of complement activation. Deficiency of MBL can lead to recurrent infections, particularly in childhood. MBL is polymorphic in the population and a deficiency of MBL is likely due to a defective protein, which cannot form oligomers and is also associated with some autoimmune diseases such as rheumatoid arthritis.
References in periodicals archive ?
As blood enters the device, it is mixed with tiny magnetic beads 128 nanometers in diameter that are coated with a genetically engineered version of a natural immune system protein called mannose binding lectin (MBL).
Studies related to immune function have focused on a number of candidate genes such as, mannose binding lectin (MBL2), intedeukin 1-alpha, (ILIA), storkhead box 1 (STOX1), and cytoxic T lymphocyte associated 4 (CTLA4) with variable results (3, 4).
LP is activated by binding of mannose binding lectin (MBL) or ficolin to pathogen-associated molecular patterns (PAMPs) on the surface of microbes.
A haemolytic assay was developed based on the principle of yeast induced lysis of bystander chicken erythrocytes for the estimation of functional mannose binding lectin levels in human serum (15).
Diseases associations of mannose binding lectin and potential of replacement therapy.
Mannose binding lectin acute phase activity in patients with severe infection.
Mannose binding lectin genotypes influence recovery from hepatitis B virus infection.
Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina.
Mannose binding lectin gene mutations are associated with progression of liver disease in chronic hepatitis B infection.
Case control studies have found significant associations between tuberculosis and gene polymorphisms like human leukocyte antigen (HLA) (2) and non-HLA genes such as natural resistance associated macrophage protein (NRAMP1) (3), vitamin D receptor (VDR) (4), mannose binding lectin (MBL) (5), interleukin-1 (IL-1) (6), IL-10 (7) and IL-12 receptor (8).