Mallory body

(redirected from Mallory-Denk body)

Mallory body

[mal′ərē]
Etymology: Frank B. Mallory, American pathologist, 1862-1941; AS, bodig, body
an eosinophilic cytoplasmic inclusion, alcoholic hyalin, found in the liver cells. It is typically, but not always, associated with acute alcoholic liver injury. See also cirrhosis.

Mallory body

One or more aggregates of randomly oriented paranuclear eosinophilic microfilaments (which stain for cytokeratin, p62 and ubiquitin). While Mallory bodies are classically seen in alcoholic liver disease, especially if centrizonal, but may also occur in alcoholic steatohepatitis (ASH), non-alcoholic steatohepatitis (NASH), primary biliary cirrhosis, primary sclerosing hepatitis, hepatitis C, Wilson’s disease, abetalipoproteinaemia, Indian childhood cirrhosis, intestinal bypass surgery for morbid obesity, corticosteroid therapy, amiodarone therapy, Weber-Christian disease, perhexiline maleate hepatitis, diethylaminoethoxyhexestrol-induced hepatitis, fatty liver in obesity, diabetes, idiopathic fatty liver, postintestinal resection, radiation pneumonitis, asbestosis, and idiopathic cirrhosis. They may also be seen in neoplasia: hepatocellular carcinoma, macro regenerative nodules, focal nodular hyperplasia and dysplastic nodules.

Mallory body

(mal′ŏ-rē) [G. Kenneth Mallory, U.S. pathologist, 1900–1986]
An inclusion body found in liver cells, especially in diseases caused by the excessive consumption of alcohol. Mallory bodies are composed of collections of intermediate filaments.
References in periodicals archive ?
SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes.