malignant transformation


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malignant transformation

the changes that a normal cell undergoes as it becomes a cancerous cell. See also carcinogenesis.

malignant transformation

The constellation of changes in the growth properties of cells in culture evoked by various agents (e.g., radiation, toxins and viruses) that result in development of neoplasms with metastatic potential. The ability to metastasise is generally regarded as the defining marker of a tumour as being malignant.

malignant transformation

Oncology The constellation of changes in the growth properties of cells in culture evoked by various agents–eg, radiation, toxins, and viruses that result in development of tumors
References in periodicals archive ?
Chronic exposure to arsenic causes malignant transformation of various animal and human cells.
Toll receptor activation has been related to malignant transformation.
Undescended testes carry a higher potential for malignant transformation than normally descended testis.
The combined inhibitory effects of different plant chemicals are expected to be particularly beneficial to, for example, smokers, former smokers or individuals with heavily tanned skin, who carry thousands of cells already initiated for malignant transformation," Margaret Hanausek said.
New instrument reveals the impact of genetic and nutrient factors in the malignant transformation of cancer cells.
Malignant transformation of polyps is typically a slow process, so the initial assumption was that all these were missed lesions.
Malignant transformation of ovarian dermoid cysts is rare, with the incidence at approximately 1% to 2% of all ovarian neoplasms.
Biopsies demonstrated numerous yeast forms consistent with histoplasmosis capsulatum and no malignant transformation.
According to the report, the long-term forced expression of telomerase by human fibroblasts (skin cells) grown in culture did not result in any of the cellular changes typically associated with malignant transformation, including the development of chromosomal abnormalities or the loss of contact inhibition, a normal process by which cells stop growing when they touch other cells.
He and his colleagues have demonstrated that a cancer-associated gene experimentally targeted to be expressed in the lens can produce malignant transformation there.
The results also show that malignant salivary gland tumors have more genomic imbalances than benign salivary gland tumors, and that certain genomic imbalances appear to be related to malignant transformation of benign tumors.
We report what is to the best of our knowledge the first case of malignant transformation of a giant cell tumor of the larynx.

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