malignant transformation


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malignant transformation

the changes that a normal cell undergoes as it becomes a cancerous cell. See also carcinogenesis.

malignant transformation

The constellation of changes in the growth properties of cells in culture evoked by various agents (e.g., radiation, toxins and viruses) that result in development of neoplasms with metastatic potential. The ability to metastasise is generally regarded as the defining marker of a tumour as being malignant.

malignant transformation

Oncology The constellation of changes in the growth properties of cells in culture evoked by various agents–eg, radiation, toxins, and viruses that result in development of tumors
References in periodicals archive ?
Von Hippel-Lindau disease (VHL), also known as Familial cerebello retinal angiomatosis, is a rare genetic disorder characterised by visceral cysts and benign tumours with potential for subsequent malignant transformation.
If the patient chooses to clinically monitor the lesion, he or she should be informed that a full-thickness excision with wide margins will have to be performed if malignant transformation occurs.
2] Thus, OSCC constitutes a major health challenge with increased need for research and identification of biomarkers which can help predict malignant transformation.
EVER genes are transcribed in human skin keratinocytes, T lymphocytes, B lymphocytes, and NK cells, thereby impairing CMI and causing persistence of EV-associated HPV types and uncontrolled proliferation of stem cells and transient amplifying cells infected with HPV5 and HPV8, causing malignant transformation of some lesions (1, 2).
Malignant transformation of multiple familial trichoepithelioma: case report and literature review.
The plethora of histopathological presentations of SP is further complicated by malignant transformation in about 11% of patients of IP, the malignancy can be synchronous or may appear after resection of papilloma (metachronous).
2] A malignant tumour that arises in a pre-existing mature teratoma is called teratoma with malignant transformation, [3] which occurs in 1-3% of all mature teratomas.
9) No follow-up studies have been published, but based on the lack of literature demonstrating recurrence or malignant transformation after removal, it has been accepted that removal is the standard of care.
Objective: To determine the relationship of age, gender and other associated risk factors linked with malignant transformation of oral submucous fibrosis into oral squamous cell carcinoma.
Objective: Multiple myeloma (MM) represents a unique model to investigate cancer stem cells (CSCs), circulating tumour cells (CTCs), and the mechanisms of malignant transformation and chemoresistance.
According to the theory by Vogelstein, colorectal carcinogenesis involves a series of successive changes in the normal colonic mucosa, starting with excessive proliferation and focal disorders of intestinal crypts, followed by adenoma and its subsequent malignant transformation.
Oral submucous fibrosis (OSF) is a chronic, progressive condition attributed chiefly to areca nut (betel nut) chewing and carries significant potential for malignant transformation (2-8%).

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