MAD1L1

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MAD1L1

A gene on chromosome 7p22 that encodes a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate, and which may recruit MAD2L1 to unattached kinetochores. MAD1L2 binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
References in periodicals archive ?
The MAD1 adhesin of Metarhizium anisopliae links adhesion with blastospore production and virulence to insects, and the MAD2 adhesin enables attachment to plants.
The MAD2 data centre is adjacent to Interxion's MAD1 data centre in the heart of Madrid's "Silicon Alley" and will offer customers the same rich connectivity options as MAD1, which houses over 70 carriers, the broadest connectivity in Spain.
Proteins and protein complexes including the Chromosomal Passenger complex (AuroraB Survivin Borealin INCENP; CPC), Mps1, Bub1, BubR1, Bub3, Mad1, spindly, dynenin-dynactin and the Anaphase Promoting Complex (APC) regulate correct progression of cell division by participating in the quality control mechanism called the spindle checkpoint ensuring the correct KT-MT attachments.
12 September 2012 - US food group Kraft Foods Inc (NASDAQ:KFT) said it was buying the 50% not yet owned in Moroccan cookie maker Bimo from investor National Investment Co (SNI) for MAD1.