MAD1L1

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MAD1L1

A gene on chromosome 7p22 that encodes a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate, and which may recruit MAD2L1 to unattached kinetochores. MAD1L2 binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
References in periodicals archive ?
The MAD2 data centre is adjacent to Interxion's MAD1 data centre in the heart of Madrid's "Silicon Alley" and will offer customers the same rich connectivity options as MAD1, which houses over 70 carriers, the broadest connectivity in Spain.
In September 2009, MAP reported that OCP had managed to achieve turnover of MAD1.