Mad Honey

Nectar derived from pollens of certain plants—e.g., rhododendron, western azalea, California rosebay, mountain laurel, sheep laurel—containing toxic diterpenes—grayanotoxins; ingestion of ‘mad honey’ causes an abrupt attack that may simulate acute myocardial infarction
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We report herein a case of a patient with mad honey intoxication mimicking acute non-ST segment elevation myocardial infarction and review the pathophysiology and diagnostic considerations.
Keywords: Mad honey intoxication Grayanotoxin- containing toxic honey Myocardial infarction.
IntroductionThe mad honey intoxication appears to be a clinical manifestation of use of grayanotoxin (GTX) isolated from the honey made by bees from the Rhododendron plant flowers mainly Ericaceae and Sapindaceae families.
Mad honey poisoning occurs after people consume honey contaminated with grayanotoxin, a chemical contained in nectar from the Rhododendron species ponticum and luteum.
Mad honey poisoning generally lasts no more than 24 hours, with symptoms of the mild form including dizziness, weakness, nausea, vomiting, excessive perspiration, hypersalivation and paraesthesia.
Mad honey poisoning is a well known condition in the Black Sea Region of Turkey.
A rare cause of atrioventricular block: mad honey intoxication.
The mad honey is widely used as an alternative therapy for the treatment of gastrointestinal diseases such as gastritis, peptic ulcer and the reduction in the coronary artery disease (CAD) risk in Black Sea region of Turkey (1).
In an accompanying editorial, he warns that "(t)oday, cases of mad honey poisoning should be anticipated everywhere (including the United States).
Mad honey is used in the Black Sea region as an alternative medicine for the treatment of gastric pains, bowel disorders, hypertension, and it is believed to be a sexual stimulant (2).
Mad honey intoxication is generally a benign condition.