CCL22

(redirected from Macrophage-derived chemokine)

CCL22

A gene on chromosome 16q13 that encodes a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. CCL22 binds CCR4 and is chemotactic for monocytes, dendritic cells, natural killer cells and activated T lymphocytes—but not for neutrophils, eosinophils or resting T lymphocytes. CCL22 may also play a role in trafficking activated T lymphocytes to sites of inflammation.
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Stimulation with tumour necrosis factor-alpha (TNF-[alpha]) and interferon-gamma (IFN-[gamma] caused a significant increase in the production of the following chemokines: thymus- and activation- regulated chemokine (TARCJ/CCL17; macrophage-derived chemokine (MDQ/CCL22; regulated on activation, normal T-cell expressed and secreted (RANTESJ/CCL5; and interleukin-8 (IL-8) in HaCaT cells.
Th2 cells are attracted to the skin by inflammatory chemokines, such as regulated on activation, normal T-cell expressed and secreted (RANTES); thymus and activation regulated chemokine (TARC); and macrophage-derived chemokine (MDC).
Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis.
The levels of thymus- and activation-regulated chamomile (TARC/CCL17; R&D Systems), macrophage-derived chemokine (MDC/CCL22; R&D Systems), and IL-12p40 (Endogen) in the BMDC culture supernatants and the levels of IFN-[gamma] (Endogen), IL-4 (Amersham), IL-10 (Endogen), and IL-17 (R&D Systems) in the supernatants of BMDCs and T-cell cocultures or splenocyte cultures were measured by ELISA according to the manufacturers' instructions.
Among his accomplishments during the past 21 years were the cloning of the first hepatitis B surface antigen protein, interferon-gamma, multiple interferon-alpha genes, bacteriacidal permeability increasing protein, tumor necrosis factor-beta (TNF- beta), platelet activating factor acetylhydrolase, and macrophage-derived chemokine.
Some of these were present in more than 3 samples: growth factors (fibroblast growth factor 4, placental growth factor), chemotactic factors [B lymphocyte chemoattractant/CXCL13, macrophage inflammatory protein (MIP)-1[beta]/CCL4, MIP-1[delta]/ CCL15, MIP-3[alpha]/CCL20, pulmonary and activation-related chemokine (PARC)/CCL18, leukemia inhibitory factor, oncostatin M], and antiinflammatory factors [tissue inhibitor of metalloproteinase (TIMP)-1, TIMP-2, macrophage-derived chemokine (MDC)/CCL22].
3] Nonstandard abbreviations: EGF, epidermal growth factor; IL-8, interleukin-8; GRO, growth-related oncoprotein; BLC, B lymphocyte chemoattractant; MIP, macrophage inflammatory protein; TIMP, tissue inhibitor of metalloproteinase; and MDC, macrophage-derived chemokine.

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