MMP12

(redirected from Macrophage elastase)

MMP12

A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 12, which degrades soluble and insoluble elastin and thus is thought to be involved in tissue injury and remodelling.

Molecular pathology
MMP12 may play a key role in aneurysm formation and emphysema.
Mentioned in ?
References in periodicals archive ?
The findings--which are consistent with laboratory evidence that smoking-induced activation of vaginal macrophage elastase may play a role in organ prolapse--suggest that smoking is a modifiable risk factor for pelvic organ prolapse.
The findings, which are consistent with laboratory data showing that smoking-induced activation of vaginal macrophage elastase may contribute to the pathogenesis of organ prolapse, suggest that smoking is a modifiable risk factor for pelvic organ prolapse.

Full browser ?