macroglobulinemia /mac·ro·glob·u·lin·emia/ (-glob″ūl-in-ēm´e-ah) increased levels of macroglobulins in the blood.
macroglobulinemia
macroglobulinemia [mak″ro-glob″u-lin-e´me-ah]
Waldenström's macroglobulinemia a plasma cell dyscrasia resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology that secrete an IgM M component, diffuse infiltration of bone marrow, weakness, fatigue, bleeding disorders, and visual disturbances.
mac·ro·glob·u·li·ne·mi·a (m k r -gl by -l-n  m-)n. An abnormally large number of macroglobulins in the blood serum. |
macroglobulinemia
[mak′rōglob′yoo͡linē′mē·ə]
Etymology: Gk, makros + L, globulus, small ball; Gk, haima, blood
a form of monoclonal gammopathy in which immunoglobulin is overproduced by the clones of a plasma B cell in response to an antigenic signal. Increased viscosity of the blood may result in circulatory impairment, weakness, neurologic disorders, and fatigue. Normal immunoglobulin synthesis is decreased, and the person is susceptible to infection, particularly bacterial pneumonia and septicemia. Treatment may include therapeutic plasma exchange to lower the viscosity. Also spelled macroglobulinaemia. Also called Waldenström's macroglobulinemia. See also multiple myeloma.
macroglobulinemia [mak″ro-glob″u-lin-e´me-ah]
increased levels of macroglobulins in the blood.
Waldenström's macroglobulinemia a type of plasma cell dyscrasia with cells having lymphocytic, plasmacytic, or intermediate morphology and secreting IgM M-component. There is diffuse infiltration of bone marrow and in many cases also of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades.
macroglobulinemia
increased levels of immunoglobulin M in the blood.
Waldenström's macroglobulinemia
a monoclonal gammopathy in which there are increased levels of IgM as a result of leukemia affecting IgM-producing B lymphocytes.
Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
| ?Page tools | ||
|---|---|---|
|