macroglobulinemia /mac·ro·glob·u·lin·emia/ (-glob″ūl-in-ēm´e-ah) increased levels of macroglobulins in the blood.
macroglobulinemia
Waldenström's macroglobulinemia a plasma cell dyscrasia resembling leukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology that secrete an IgM M component, diffuse infiltration of bone marrow, weakness, fatigue, bleeding disorders, and visual disturbances.
mac·ro·glob·u·li·ne·mi·a (m k r -gl by -l-n  m-)n. An abnormally large number of macroglobulins in the blood serum. |
macroglobulinemia
[mak′rōglob′yoo͡linē′mē·ə]
Etymology: Gk, makros + L, globulus, small ball; Gk, haima, blood
a form of monoclonal gammopathy in which immunoglobulin is overproduced by the clones of a plasma B cell in response to an antigenic signal. Increased viscosity of the blood may result in circulatory impairment, weakness, neurologic disorders, and fatigue. Normal immunoglobulin synthesis is decreased, and the person is susceptible to infection, particularly bacterial pneumonia and septicemia. Treatment may include therapeutic plasma exchange to lower the viscosity. Also spelled macroglobulinaemia. Also called Waldenström's macroglobulinemia. See also multiple myeloma.
macroglobulinemia
increased levels of immunoglobulin M in the blood.
Waldenström's macroglobulinemia
a monoclonal gammopathy in which there are increased levels of IgM as a result of leukemia affecting IgM-producing B lymphocytes.
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