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Infections caused by laboratory exposure to hemorrhagic fever viruses * Virus Incident Ebola Fingerstick while manipulating infected guinea pig tissue, 1977 (5); percutaneous exposure to blood from a Zaire Ebola virus-infected rodent, 2004 (7) Marburg 3 laboratory acquired infections since the mid-1980s; 1 death occurred in Russia; no details available (8) Crimean-Congo 8 cases before 1980 compiled by SALS; no details hemorrhagic fever available (9) Lassa 1 case reported in 1970 with limited details provided (10) Junin 21 cases before 1980 compiled by SALS; no details available (9) Machupo 1 person exposed to aerosolized blood from a broken test tube (11) * SALS, Subcommittee on Arbovirus Laboratory Safety.
Because physicians suspected BHF, patients received supportive therapy, including intravenous hydration, corticoids, antipyretic drugs, antimicrobial drugs, and blood transfusions from donors who had survived Machupo virus infection.
Sequence analyses confirmed the isolates as Machupo virus (Figure).
admission isolation Virus ([dagger]) 1 1972 Oct 18 Machupo 2 1975 Oct 42 Machupo 3 1976 Oct 21 JEB 4 1977 Sep 14 Machupo 5 1977 Sep 14 Machupo 6 1978 May 11 Dengue 7 1978 May 8 Dengue 8 1978 Jun 17 Lassa 9 1978 Jun 17 Lassa 10 1978 Jul 8 Lassa 11 1978 Nov 14 Lassa 12 1979 May 20 Lassa 13 ([paragraph]) 1979 Jul 21 Lassa 14 1979 Nov 20 Lassa 15 1981 May 14 Ebola/Lassa 16 1982 Oct 14 Junin 17 1982 Dec 21 Junin 18 1983 Jan 3 Rift Valley fever 19 1983 Apr 14 Junin 20 1985 May 4 Junin 21 2004 Feb 21 Ebola Therapy ([double Comments Patient no.
natalensis is the only host of Lassa virus, natural nidality may occur in a similar fashion as that described for Bolivian hemorrhagic fever caused by Machupo virus.
The term "viral hemorrhagic fever" characterizes a severe multisystem syndrome associated with fever, shock, and bleeding diathesis caused by infection with any of several RNA viruses, including Ebola virus and Marburg virus (MARV) (family Filoviridae); Lassa virus (LASV) and the South American hemorrhagic fever viruses Guanarito virus, Junin virus, Machupo virus, and Sabifi virus (Arenaviridae); Rift Valley fever virus (RVFV), Crimean-Congo hemorrhagic fever virus (CCHFV), and hantaviruses (Bunyaviridae); and Kyasanur Forest disease virus (KFDV), Omsk hemorrhagic fever virus, yellow fever virus (YFV), and dengue viruses (Flaviviridae) (1,2).
callosus is the reservoir of Machupo virus, the arenavirus linked to Bolivian hemorrhagic fever, in the BHF-endemic area of El Beni (18).
botulinum 94-86 Sabia virus 94-88 Machupo virus 95-16 Unknown 95-40 Dengue type 4 virus 95-55 Ebola virus 95-61 Francisella tularensis 98-23 Rift Valley fever virus 98-28 C.
In addition to smallpox, SIGA has antiviral programs targeting other Category A pathogens, including arenaviruses (Lassa fever, Junin, Machupo, Guanarito, Sabia, and lymphocytic choriomeningitis), dengue virus, and the filoviruses (Ebola and Marburg).
The Tacaribe (New World) complex includes Whitewater Arroyo virus (WWAV), Tamiami (TAMV), Allpahuayo (ALLV), Flexal (FLEV), Parana (PARV), Pichinde (PICV), Pirital (PIRV), Amapari (AMAV), Guanarito (GTOV), Junin (JUNV), Machupo (MACV), Sabia (SABV), Tacaribe (TCRV), Oliveros (OLVV), and Latino (LATV) viruses.
Listeria monocytogenes; Lymphocytic choriomeningitis virus (LCMV); Machupo virus (Bolivian hemorrhagic fever); Marburg virus; measles (Edmonston) virus (MeV); Mycobacterium spp.