MYOD1

MYOD1

A gene on chromosome 11p15.4 that regulates myogenesis by encoding MyoD1, a nuclear phosphoprotein with partial homology to the myc family of oncoproteins, which binds to the enhancer sequences of the muscle-specific creatine phosphokinase gene, inhibiting DNA synthesis and cell proliferation. MyoD1 belongs to the basic helix-loop-helix (bHLH) transcription factor family and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenesis, and is involved in muscle regeneration.
Mentioned in ?
References in periodicals archive ?
Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits.
Hypermethylation of the MYOD1 gene is a novel prognostic factor in patients with colorectal cancer.
The 15 screened genes were chosen for (a) their demonstrated role in regulating cellular adhesion and their possible role in metastasis (TIMP3, CDH1, CDH13, and APC), or (b) their putative role in carcinogenesis (PPP1R13B, HSPA2, HSD17B4, ESR1, GSTP1, CYP1B1, BRCA1, MYOD1, SOCS1, TITF1, and GSTM3).
3 R-5'-CCACGGGTTCGAGTACCTTC-3' MYOD1 F 5'-AGCAAGTTTCTGGCAACCCT-3' 143 NM_001040478.
A total of 15 primer pairs were tested for amplification and sequencing of 13 candidate genes (PTH, CSF2, FOLR1, BDNF, LDHA, RPS13, ADM, CAT, WT1, FSHB, MYOD1, IL4 and ADRB2).
Knockout mouse experiments showed that MYF5 and MYOD1 do affect muscle development, although they are redundant to a certain extent.
A relationship between the PCR-RFLP polymorphism in porcine MYOG, MYOD1 and MYF5 genes and microstructural characteristics of m.