MYOD1

MYOD1

A gene on chromosome 11p15.4 that regulates myogenesis by encoding MyoD1, a nuclear phosphoprotein with partial homology to the myc family of oncoproteins, which binds to the enhancer sequences of the muscle-specific creatine phosphokinase gene, inhibiting DNA synthesis and cell proliferation. MyoD1 belongs to the basic helix-loop-helix (bHLH) transcription factor family and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenesis, and is involved in muscle regeneration.
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Investigation of LDHA and COPB1 as candidate genes for muscle development in the MYOD1 region of pig chromosome 2.
p53, MYC, MYOD1, ZEB 1 and 2, and p27Kip1 regulate the transcription of miR-34, miR-17, miR-1, miR-15a, miR-200, and miR-221 clusters respectively.
The MYOD1 gene, whose primers and probe described as prescribed, was chosen as the internal control gene to normalize for suitable amounts of bisulfite-treated DNA from every sample.
Increases in the relative abundance of HDAC2 and MYOD1, most obvious from 24 to 72 h then followed by apparent decreases were very similar (Figure 4D).
Hypermethylation of the MYOD1 gene is a novel prognostic factor in patients with colorectal cancer.
Effects of variation in porcine MYOD1 gene on muscle fiber characteristics, lean meat production, and meat quality traits.
The 15 screened genes were chosen for (a) their demonstrated role in regulating cellular adhesion and their possible role in metastasis (TIMP3, CDH1, CDH13, and APC), or (b) their putative role in carcinogenesis (PPP1R13B, HSPA2, HSD17B4, ESR1, GSTP1, CYP1B1, BRCA1, MYOD1, SOCS1, TITF1, and GSTM3).
23,24) Patients with RMS harboring this mutation had a poor outcome; none of the 7 older RMS patients with MYOD1 mutation survived 9 years past diagnosis in one series, (23) and none of 4 pediatric RMS patients with MYOD1 mutation survived in another series.
3 R-5'-CCACGGGTTCGAGTACCTTC-3' MYOD1 F 5'-AGCAAGTTTCTGGCAACCCT-3' 143 NM_001040478.
A total of 15 primer pairs were tested for amplification and sequencing of 13 candidate genes (PTH, CSF2, FOLR1, BDNF, LDHA, RPS13, ADM, CAT, WT1, FSHB, MYOD1, IL4 and ADRB2).